JVI Figure table search 04
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lewis, A. J.
Right arrow Articles by Lipkin, W. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lewis, A. J.
Right arrow Articles by Lipkin, W. I.

 Previous Article  |  Next Article 

Journal of Virology, March 1999, p. 2541-2546, Vol. 73, No. 3
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Effect of Immune Priming on Borna Disease

Ann J. Lewis,1,2 J. Lindsay Whitton,3 Carolyn G. Hatalski,2 Herbert Weissenböck,1,4 and W. Ian Lipkin1,2,5,*

Departments of Neurology,1 Anatomy and Neurobiology,2 and Microbiology and Molecular Genetics,5 University of California, Irvine, California 92697-4292; and Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 920373; and Institute of Pathology, University of Veterinary Medicine, Vienna, Austria4

Received 23 April 1998/Accepted 30 November 1998

Borna disease virus (BDV) is a neurotropic virus with a broad host and geographic range. Lewis rats were immunized against BDV with a recombinant vaccinia virus expressing the BDV nucleoprotein and were later infected with BDV to evaluate protection against Borna disease (BD). Relative to animals that were not immunized, immunized animals had a decreased viral burden after challenge with infectious virus, more marked inflammation, and aggravated clinical disease. These data suggest that a more robust immune response in Borna disease can reduce viral load at the expense of increased morbidity.

* Corresponding author. Mailing address: Laboratory for Neurovirology and Microbial Pathogenesis, University of California, Irvine, CA 92697-4292. Phone: (949) 824-6193. Fax: (949) 824-1229. E-mail: ilipkin{at}uci.edu.

Journal of Virology, March 1999, p. 2541-2546, Vol. 73, No. 3
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
J. Bacteriol. Mol. Cell. Biol. Microbiol. Mol. Biol. Rev.
Clin. Vaccine Immunol. ALL ASM JOURNALS

Copyright © 1999 by the American Society for Microbiology. All rights reserved.