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Journal of Virology, March 1999, p. 2541-2546, Vol. 73, No. 3
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Effect of Immune Priming on Borna Disease
Ann J.
Lewis,1,2
J. Lindsay
Whitton,3
Carolyn G.
Hatalski,2
Herbert
Weissenböck,1,4 and
W. Ian
Lipkin1,2,5,*
Departments of
Neurology,1
Anatomy and
Neurobiology,2 and
Microbiology and
Molecular Genetics,5 University of
California, Irvine, California 92697-4292; and
Department
of Neuropharmacology, The Scripps Research Institute, La Jolla,
California 920373; and
Institute of
Pathology, University of Veterinary Medicine, Vienna,
Austria4
Received 23 April 1998/Accepted 30 November 1998
Borna disease virus (BDV) is a neurotropic virus with a broad host
and geographic range. Lewis rats were immunized against BDV with a
recombinant vaccinia virus expressing the BDV nucleoprotein and were
later infected with BDV to evaluate protection against Borna disease
(BD). Relative to animals that were not immunized, immunized
animals had a decreased viral burden after challenge with infectious
virus, more marked inflammation, and aggravated clinical disease. These
data suggest that a more robust immune response in Borna disease can
reduce viral load at the expense of increased morbidity.
*
Corresponding author. Mailing address: Laboratory for
Neurovirology and Microbial Pathogenesis, University of California, Irvine, CA 92697-4292. Phone: (949) 824-6193. Fax: (949) 824-1229. E-mail: ilipkin{at}uci.edu.
Journal of Virology, March 1999, p. 2541-2546, Vol. 73, No. 3
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
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