This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lewis, A. J.
Right arrow Articles by Lipkin, W. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lewis, A. J.
Right arrow Articles by Lipkin, W. I.

 Previous Article  |  Next Article 

Journal of Virology, March 1999, p. 2541-2546, Vol. 73, No. 3
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Effect of Immune Priming on Borna Disease

Ann J. Lewis,1,2 J. Lindsay Whitton,3 Carolyn G. Hatalski,2 Herbert Weissenböck,1,4 and W. Ian Lipkin1,2,5,*

Departments of Neurology,1 Anatomy and Neurobiology,2 and Microbiology and Molecular Genetics,5 University of California, Irvine, California 92697-4292; and Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 920373; and Institute of Pathology, University of Veterinary Medicine, Vienna, Austria4

Received 23 April 1998/Accepted 30 November 1998

Borna disease virus (BDV) is a neurotropic virus with a broad host and geographic range. Lewis rats were immunized against BDV with a recombinant vaccinia virus expressing the BDV nucleoprotein and were later infected with BDV to evaluate protection against Borna disease (BD). Relative to animals that were not immunized, immunized animals had a decreased viral burden after challenge with infectious virus, more marked inflammation, and aggravated clinical disease. These data suggest that a more robust immune response in Borna disease can reduce viral load at the expense of increased morbidity.

* Corresponding author. Mailing address: Laboratory for Neurovirology and Microbial Pathogenesis, University of California, Irvine, CA 92697-4292. Phone: (949) 824-6193. Fax: (949) 824-1229. E-mail: ilipkin{at}uci.edu.

Journal of Virology, March 1999, p. 2541-2546, Vol. 73, No. 3
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Ohtaki, N., Kamitani, W., Watanabe, Y., Hayashi, Y., Yanai, H., Ikuta, K., Tomonaga, K. (2007). Downregulation of an Astrocyte-Derived Inflammatory Protein, S100B, Reduces Vascular Inflammatory Responses in Brains Persistently Infected with Borna Disease Virus. J. Virol. 81: 5940-5948 [Abstract] [Full Text]  
  • Hausmann, J., Pagenstecher, A., Baur, K., Richter, K., Rziha, H.-J., Staeheli, P. (2005). CD8 T Cells Require Gamma Interferon To Clear Borna Disease Virus from the Brain and Prevent Immune System-Mediated Neuronal Damage. J. Virol. 79: 13509-13518 [Abstract] [Full Text]  
  • Hausmann, J., Baur, K., Engelhardt, K. R., Fischer, T., Rziha, H.-J., Staeheli, P. (2005). Vaccine-induced protection against Borna disease in wild-type and perforin-deficient mice. J. Gen. Virol. 86: 399-403 [Abstract] [Full Text]  
  • Henkel, M., Planz, O., Fischer, T., Stitz, L., Rziha, H.-J. (2005). Prevention of Virus Persistence and Protection against Immunopathology after Borna Disease Virus Infection of the Brain by a Novel Orf Virus Recombinant. J. Virol. 79: 314-325 [Abstract] [Full Text]  
  • Fassnacht, U., Ackermann, A., Staeheli, P., Hausmann, J. (2004). Immunization with dendritic cells can break immunological ignorance toward a persisting virus in the central nervous system and induce partial protection against intracerebral viral challenge. J. Gen. Virol. 85: 2379-2387 [Abstract] [Full Text]  
  • Hashimoto, Y., Chen, H.-S., Cunningham, C., Malik, T. H., Lai, P. K. (2003). Two Major Histocompatibility Complex Class I-Restricted Epitopes of the Borna Disease Virus p10 Protein Identified by Cytotoxic T Lymphocytes Induced by DNA-Based Immunization. J. Virol. 77: 6076-6081 [Abstract] [Full Text]  
  • Solbrig, M. V., Schlaberg, R., Briese, T., Horscroft, N., Lipkin, W. I. (2002). Neuroprotection and Reduced Proliferation of Microglia in Ribavirin-Treated Bornavirus-Infected Rats. Antimicrob. Agents Chemother. 46: 2287-2291 [Abstract] [Full Text]  
  • Jordan, I., Briese, T., Averett, D. R., Lipkin, W. I. (1999). Inhibition of Borna Disease Virus Replication by Ribavirin. J. Virol. 73: 7903-7906 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»