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Journal of Virology, February 1999, p. 1724-1728, Vol. 73, No. 2
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Gamma Interferon Is a Major Suppressive Factor Produced by Activated Human Peripheral Blood Lymphocytes That Is Able To Inhibit Foamy Virus-Induced Cytopathic Effects

Valeria Falcone,1 Matthias Schweizer,1 Antonio Toniolo,2 Dieter Neumann-Haefelin,1 and Andreas Meyerhans1,*

Abteilung Virologie, Institut für Medizinische Mikrobiologie und Hygiene, Universität Freiburg, D-79104 Freiburg, Germany,1 and Dipartimento di Scienze Cliniche e Biologiche, Universitá di Pavia, I-27100 Varese, Italy2

Received 6 July 1998/Accepted 14 October 1998

The activation of human peripheral blood lymphocytes by mitogens or by triggering the T-cell receptor with anti-CD3 antibodies leads to the production of a potent soluble inhibitory activity against foamy virus-induced cytopathic effects in vitro. The inhibitory activity acts in a species-specific manner. As a consequence, the isolation of foamy viruses from blood lymphocytes of infected humans is accelerated in a heterologous coculture system. Antibodies against gamma interferon (IFN-gamma ) are able to suppress most of the inhibitory activity, suggesting that IFN-gamma is the dominant component.

* Corresponding author. Mailing address: Abteilung Virologie, Institut für Medizinische Mikrobiologie und Hygiene, Klinikum Homburg, Haus 47, Universität des Saarlandes, D-66421 Homburg/Saar, Germany. Phone: 49 6841 16 3990. Fax: 49 6841 16 3980. E-mail: Andreas.Meyerhans{at}med-rz.uni-sb.de.

Journal of Virology, February 1999, p. 1724-1728, Vol. 73, No. 2
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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