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Journal of Virology, February 1999, p. 1668-1671, Vol. 73, No. 2
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Exponential Fitness Gains of RNA Virus Populations Are Limited by Bottleneck Effects

Isabel S. Novella,1,* Josep Quer,1,dagger Esteban Domingo,2 and John J. Holland1

Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093-0116,1 and Centro de Biologia Molecular "Severo Ochoa" (Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid), Cantoblanco, 28049 Madrid, Spain2

Received 13 July 1998/Accepted 5 November 1998

Fitness is a parameter that quantitatively measures adaptation of a virus to a given environment. We have previously reported exponential fitness gains of large populations of vesicular stomatitis virus replicating in a constant environment (I. S. Novella et al., Proc. Natl. Acad. Sci. USA 92:5841-5844, 1995). In this paper, we report that during long-term passage of such large viral populations, fitness values reached a high-fitness plateau during which stochastic fitness variations were observed. This effect appears likely to be due to bottleneck effects on very high fitness populations.

* Corresponding author. Present address: Dept. of Microbiology and Immunology, Medical College of Ohio, Health Education Building, 3055 Arlington Ave., Toledo, OH 43614-5806. Phone: (419) 383-6442. Fax: (419) 383-3002. E-mail: isabel{at}mco.edu.

dagger Present address: Recerca Medicina Interna, Area Investigacion B, Hospital Vall D'Hebron, Pg. Vall D'Hebron 119-129, 08035 Barcelona, Spain.

Journal of Virology, February 1999, p. 1668-1671, Vol. 73, No. 2
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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