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Journal of Virology, February 1999, p. 1665-1667, Vol. 73, No. 2
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Perforin Is Essential for Control of Ectromelia Virus but Not Related Poxviruses in Mice

Arno Müllbacher,1,* Ron Tha Hla,1 Crisan Museteanu,2 and Markus M. Simon2

Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia,1 and Max-Planck-Institut für Immunbiologie, Freiburg, Germany2

Received 27 July 1998/Accepted 15 October 1998

Lack of perforin renders the relatively resistant mouse strain C57BL/6 highly susceptible to the natural mouse pathogen ectromelia virus, a cytopathic orthopoxvirus. This is indicated by increased mortality, elevated virus titers and pathology in liver and spleen, and increased levels of liver enzymes in blood. Cowpox virus on the other hand is more virulent in the presence of perforin than in its absence. An additional lack of granzyme A which together with perforin is a constituent of cytoplasmic granules from cytotoxic T cells increases the virulence of cowpox virus.

* Corresponding author. Mailing address: Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, P.O. Box 334, Canberra, ACT 2601, Australia. Phone: 61 26 249-4392. Fax: 61 26 248-6271. E-mail: arno.mullbacher{at}anu.edu.au.

Journal of Virology, February 1999, p. 1665-1667, Vol. 73, No. 2
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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