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Journal of Virology, February 1999, p. 1655-1660, Vol. 73, No. 2
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Coreceptor Specificity of Temporal Variants of Simian Immunodeficiency Virus Mne

Jason T. Kimata,1 John J. Gosink,1 Vineet N. KewalRamani,2 Lyle M. Rudensey,1 Dan R. Littman,2,3 and Julie Overbaugh1,*

Department of Microbiology, University of Washington, Seattle, Washington 98195,1 and The Skirball Institute of Biomolecular Medicine2 and Howard Hughes Medical Institute,3 New York University Medical Center, New York, New York 10016

Received 11 August 1998/Accepted 3 November 1998

The simian immunodeficiency virus (SIV) Mne envelope undergoes genetic changes that alter tropism, syncytium-inducing capacity, and antigenic properties of the emerging variant virus population during the course of an infection. Here we investigated whether the mutations in envelope of SIVMne also influence coreceptor usage. The data demonstrate that the infecting macrophage-tropic SIVMne clone as well as the envelope variants that are selected during the course of disease progression all recognize both CCR5 and Bob (GPR15) but not Bonzo (STRL33), CXCR4, or CCR3. Although it remains to be determined if there are other coreceptors specific for dualtropic or T-cell-tropic variants of SIVMne that emerge during late stages of infection, these data suggest that such SIV variants that evolve in pathogenic infections do not lose the ability to recognize CCR5 or Bob/GPR15.

* Corresponding author. Mailing address: Department of Microbiology, Box 357242, University of Washington, Seattle, WA 98195-7242. Phone: (206) 543-3146. Fax: (206) 543-8297. E-mail: overbaug{at}u.washington.edu.

Journal of Virology, February 1999, p. 1655-1660, Vol. 73, No. 2
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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