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Journal of Virology, February 1999, p. 1637-1639, Vol. 73, No. 2
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Differential Influence of Interleukin-12 in the Pathogenesis of Autoimmune and Virus-Induced Central Nervous System Demyelination

John J. Bright,1 Moses Rodriguez,2 and Subramaniam Sriram1,*

Multiple Sclerosis Research Laboratory, Vanderbilt University Medical Center, Nashville, Tennessee 37212,1 and Departments of Neurology and Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 559052

Received 10 July 1998/Accepted 3 November 1998

Experimental allergic encephalomyelitis (EAE) and Theiler's murine encephalomyelitis virus (TMEV) disease are two demyelinating diseases of the central nervous system (CNS) that serve as animal models for multiple sclerosis. Th1 cells are thought to play a role in the pathogenesis of CNS demyelination in both these diseases. We show here the differential influence of interleukin 12, a critical cytokine for the development of Th1 cells in EAE and TMEV disease.

* Corresponding author. Mailing address: Multiple Sclerosis Research Laboratory, Vanderbilt University Medical Center, 1222 VSRH, 2201 Capers Ave., Nashville, TN 37212. Phone: (615) 963-4042. Fax: (615) 321-5247. E-mail: srirams{at}ctrvax.vanderbilt.edu.

Journal of Virology, February 1999, p. 1637-1639, Vol. 73, No. 2
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Oleszak, E. L., Chang, J. R., Friedman, H., Katsetos, C. D., Platsoucas, C. D. (2004). Theiler's Virus Infection: a Model for Multiple Sclerosis. Clin. Microbiol. Rev. 17: 174-207 [Abstract] [Full Text]  
  • Bright, J. J., Natarajan, C., Muthian, G., Barak, Y., Evans, R. M. (2003). Peroxisome Proliferator-Activated Receptor-{gamma}-Deficient Heterozygous Mice Develop an Exacerbated Neural Antigen-Induced Th1 Response and Experimental Allergic Encephalomyelitis. J. Immunol. 171: 5743-5750 [Abstract] [Full Text]  
  • Natarajan, C., Bright, J. J. (2002). Curcumin Inhibits Experimental Allergic Encephalomyelitis by Blocking IL-12 Signaling Through Janus Kinase-STAT Pathway in T Lymphocytes. J. Immunol. 168: 6506-6513 [Abstract] [Full Text]  
  • Palma, J. P., Yauch, R. L., Kang, H.-K., Lee, H.-G., Kim, B. S. (2002). Preferential Induction of IL-10 in APC Correlates with a Switch from Th1 to Th2 Response Following Infection with a Low Pathogenic Variant of Theiler's Virus. J. Immunol. 168: 4221-4230 [Abstract] [Full Text]  


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