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Journal of Virology, February 1999, p. 1630-1636, Vol. 73, No. 2
Klinik für Innere Medizin
I,1
Zentrum für Molekulare Medizin
der Universität Köln,2 and
Institut für Pathologie der Universität
Köln,
Received 30 June 1998/Accepted 20 October 1998
Epstein-Barr virus is associated with several human malignancies
including Burkitt's lymphoma, nasopharyngeal carcinoma, and Hodgkin's
disease (HD). To examine the effect of Epstein-Barr virus nuclear
antigen 1 (EBNA-1) in the pathogenesis of HD, we transfected the gene
into the HD cell line L428. EBNA-1 expression was associated with
significantly enhanced CD25 expression (interleukin 2 [IL-2]-receptor
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Expression of Epstein-Barr Virus Nuclear Antigen 1 Is Associated with Enhanced Expression of CD25 in the Hodgkin Cell
Line L428
chain) in transient and stably transfected L428 cells but did not
affect the expression of IL-2 receptor
and
chains. There was no
up-regulation of the B-cell activation molecules CD23, CD30, CD39,
CD40, CD44, CD71, and CD54 (intercellular adhesion molecule 1) or
enhanced production of IL-6, IL-10, lymphotoxin alpha, and the soluble
form of CD25. Stable EBNA-1-expressing L428 cells were nontumorigenic
in SCID mice but showed enhanced lymphoma development in nonobese
diabetic-SCID mice compared to mock-transfected cells.
*
Corresponding author. Present address:
Universität Tübingen, Institut für Tropenmedizin
Sektion Humanparasitologie, Wilhelmstrasse 27, D-72074 Tübingen,
Germany. Phone: 49 7071 2980 240. Fax: 49 7071 295189. E-mail:
ail14{at}pop.rrz.uni-koeln.de.
Journal of Virology, February 1999, p. 1630-1636, Vol. 73, No. 2
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
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