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Journal of Virology, February 1999, p. 1555-1564, Vol. 73, No. 2
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

X-Linked Agammaglobulinemia Patients Are Not Infected with Epstein-Barr Virus: Implications for the Biology of the Virus

Glenda C. Faulkner,1 Scott R. Burrows,2 Rajiv Khanna,2 Denis J. Moss,2 A. Graham Bird,3 and Dorothy H. Crawford1,*

Herpesvirus Group, Department of Medical Microbiology, University of Edinburgh Medical School, Edinburgh EH8 9AG,1 and Department of Immunology, Churchill Hospital, Headington, Oxford OX3 7LJ,3 United Kingdom, and Epstein-Barr Virus Unit, Queensland Institute of Medical Research, The Bancroft Centre, Brisbane 4006, Australia2

Received 21 July 1998/Accepted 3 November 1998

Epstein-Barr virus (EBV) infects both B lymphocytes and squamous epithelial cells in vitro, but the cell type(s) required to establish primary and persistent infection in vivo has not been definitively elucidated. The aim of this study was to investigate a group of individuals who lack mature B lymphocytes due to the rare heritable disorder X-linked agammaglobulinemia in order to determine the role of the B cell in the infection process. The results show that none of these individuals harbored EBV in their blood or throat washings. Furthermore, no EBV-specific memory cytotoxic T lymphocytes were found, suggesting that they had not undergone infection in the past. In contrast, 50% of individuals were found to carry human herpesvirus 6, showing that they are infectible by another lymphotropic herpesvirus. These results add weight to the theory that B lymphocytes, and not oropharyngeal epithelial cells, may be required for primary infection with EBV.

* Corresponding author. Mailing address: Herpesvirus Group, Department of Medical Microbiology, University of Edinburgh Medical School, Teviot Pl., Edinburgh EH8 9AG, United Kingdom. Phone: 44(0)131-650-3142. Fax: 44(0)131-650-6531. E-mail: D.Crawford{at}ed.ac.uk.

Journal of Virology, February 1999, p. 1555-1564, Vol. 73, No. 2
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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