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Journal of Virology, February 1999, p. 1235-1238, Vol. 73, No. 2
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Detection and Sequence Analysis of Hepatitis B Virus Integration in Peripheral Blood Mononuclear Cells

Tomasz Laskus,1,* Marek Radkowski,2 Lian-Fu Wang,1 Marek Nowicki,3 and Jorge Rakela1

Division of Gastroenterology and Hepatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 152131; Institute of Infectious Diseases, Warsaw, Poland2; and Maternal-Child Virology Research Laboratory, University of Southern California, Los Angeles, California 900333

Received 23 July 1998/Accepted 3 November 1998

A PCR-based technique was used to detect hepatitis B virus (HBV) integration in peripheral blood mononuclear cells from patients with chronic hepatitis B. Integrated HBV DNA sequences, with virus-cell junctions located in the cohesive region between direct repeat 1 (DR1) and DR2, were found in 2 of 10 studied patients.

* Corresponding author. Mailing address: University of Pittsburgh Medical Center, BST 1513E, 200 Lothrop St., Pittsburgh, PA 15213. Phone: (412) 624-0287. Fax: (412) 383-7236. E-mail: Laskus{at}pitt.edu.

Journal of Virology, February 1999, p. 1235-1238, Vol. 73, No. 2
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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