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Journal of Virology, December 1999, p. 9843-9848, Vol. 73, No. 12
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

The Equine Herpesvirus 2 E1 Open Reading Frame Encodes a Functional Chemokine Receptor

Grazia Camarda,1 Gaia Spinetti,1 Giovanni Bernardini,1 Catherine Mair,2 Nick Davis-Poynter,2 Maurizio C. Capogrossi,1 and Monica Napolitano1,*

Laboratorio di Patologia Vascolare, Istituto Dermopatico dell'Immacolata-Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy,1 and Laboratory of Virology, Animal Health Trust, Newmarket, England2

Received 26 May 1999/Accepted 19 August 1999

Several herpesviruses contain open reading frames (ORFs) that encode potential homologs of eucaryotic genes. Equine herpesvirus 2 (EHV-2) is a gammaherpesvirus related to other lymphotropic herpesviruses such as herpesvirus saimiri and Epstein-Barr virus. The E1 ORF of EHV-2, a G protein-coupled receptor homolog, shows 31 to 47% amino acid identity with known CC chemokine receptors. To investigate whether E1 may encode a functional receptor, we cloned the E1 ORF and expressed it in stably transfected cell lines. We report here the identification of the CC chemokine eotaxin as a functional ligand for the EHV-2 E1 receptor. Chemokines are likely to play a role in the regulation of immune functions in equine hosts during EHV-2 infection and, via interaction with E1, may affect viral replication and/or escape from immune responses.

* Corresponding author. Mailing address: Laboratorio di Patologia Vascolare, Istituto Dermopatico dell'Immacolata-IRCCS, Via Monti di Creta 104, 00167 Rome, Italy. Phone: 39-06-66462431. Fax: 39-06-66462430. E-mail: m.napolitano{at}idi.it.

Journal of Virology, December 1999, p. 9843-9848, Vol. 73, No. 12
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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