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Journal of Virology, December 1999, p. 10551-10555, Vol. 73, No. 12
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

The URNA Genes of Herpesvirus Saimiri (Strain C488) Are Dispensable for Transformation of Human T Cells In Vitro

Armin Ensser,* André Pfinder, Ingrid Müller-Fleckenstein, and Bernhard Fleckenstein

Institut für Klinische und Molekulare Virologie der Universität Erlangen---Nürnberg, 91054 Erlangen, Germany

Received 1 June 1999/Accepted 13 September 1999

The herpesvirus saimiri strain C488 genome contains five genes for small nuclear RNAs, termed herpesvirus saimiri URNAs (or HSURs). Using a cosmid-based approach, all HSURs were precisely deleted from the genome. The mutant virus replicated at levels that were similar to those of wild-type viruses in OMK cells. Although the HSURs are expressed in wild-type virus-transformed human T-cell lines, the deletion does not affect viral transformation in cell culture.

* Corresponding author. Mailing address: Institut für Klinische und Molekulare Virologie der Universität Erlangen---Nürnberg, Schlossgarten 4, 91054 Erlangen, Germany. Phone: 49-9131-85-23786. Fax: 49-9131-85-1002. E-mail: ensser{at}viro.med.uni-erlangen.de.

Journal of Virology, December 1999, p. 10551-10555, Vol. 73, No. 12
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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