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Journal of Virology, December 1999, p. 10536-10539, Vol. 73, No. 12
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Dependence of Echovirus 9 on the Enterovirus RNA Replication Inhibitor 2-(alpha -Hydroxybenzyl)-Benzimidazole Maps to Nonstructural Protein 2C

Dirk Hadaschik, Marcus Klein, Holger Zimmermann,dagger Hans J. Eggers, and Birgit Nelsen-Salz*

Institut für Virologie der Universität zu Köln, 50935 Cologne, Germany

Received 16 February 1999/Accepted 8 September 1999

HBB [2-(alpha -hydroxybenzyl)-benzimidazole] selectively inhibits RNA synthesis of most enteroviruses. However, isolation of HBB-dependent variants is possible. Sequence analysis and characterization of recombinant viruses revealed that HBB dependence maps to the nonstructural protein 2C. A single point mutation at position C4782U is sufficient to establish the HBB-dependent phenotype in our echovirus 9 model.

* Corresponding author. Mailing address: Institut für Virologie der Universität zu Köln, Fürst-Pückler-Str. 56, 50935 Cologne, Germany. Phone: (49) 221-4783924. Fax: (49) 221-4783902. E-mail: birgit.nelsen-salz{at}medizin.uni-koeln.de.

dagger Present address: Institute of Molecular and Cell Biology, Singapore 117609, Republic of Singapore.

Journal of Virology, December 1999, p. 10536-10539, Vol. 73, No. 12
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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