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Journal of Virology, December 1999, p. 10503-10507, Vol. 73, No. 12
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Glycoproteins gM and gN of Pseudorabies Virus Are Dispensable for Viral Penetration and Propagation in the Nervous Systems of Adult Mice

Marie Jo Masse,1 Alice Jöns,2 Johannes M. Dijkstra,2 Thomas C. Mettenleiter,2 and Anne Flamand1,*

Laboratoire de Génétique des Virus, CNRS, F-91198 Gif-sur-Yvette Cedex, France,1 and Institute of Molecular Biology, Friedrich-Loeffler-Institutes, Federal Research Centre for Virus Diseases of Animals, D-17498 Insel Riems, Germany2

Received 20 May 1999/Accepted 31 August 1999

Glycoproteins gM and gN are conserved throughout the herpesviruses but are dispensable for viral replication in cell cultures. To assay for a function of these proteins in infection of an animal, deletion mutants of pseudorabies virus lacking gM or gN and corresponding revertants were analyzed for the ability to penetrate and propagate in the nervous systems of adult mice after intranasal inoculation. We demonstrate that neither of the two glycoproteins is required for infection of the nervous systems of mice by pseudorabies virus.

* Corresponding author. Mailing address: Laboratoire de Génétique des Virus, CNRS, F-91198 Gif-sur-Yvette Cedex, France. Phone: (33) 1 69 82 38 43. Fax: (33) 1 69 82 43 08. E-mail: anne.flamand{at}gv.cnrs-gif.fr.

Journal of Virology, December 1999, p. 10503-10507, Vol. 73, No. 12
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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Copyright © 1999 by the American Society for Microbiology. All rights reserved.