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Journal of Virology, November 1999, p. 9650-9654, Vol. 73, No. 11
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Requirement for CD40 Ligand, CD4+ T Cells, and B Cells in an Infectious Mononucleosis-Like Syndrome

James W. Brooks,dagger Ann Marie Hamilton-Easton, Jan P. Christensen, Rhonda D. Cardin,Dagger Charles L. Hardy, and Peter C. Doherty*

Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105

Received 5 May 1999/Accepted 22 July 1999

Respiratory challenge with the murine gammaherpesvirus 68 (gamma HV-68) results in productive infection of the lung, the establishment of latency in B lymphocytes and other cell types, transient splenomegaly, and prolonged clonal expansion of activated CD8+ CD62Llo T cells, particularly a Vbeta 4+ CD8+ population that is found in mice with different major histocompatibility complex (MHC) haplotypes. Aspects of the CD8+-T-cell response are substantially modified in mice that lack B cells, CD4+ T cells, or the CD40 ligand (CD40L). The B-cell-deficient mice show no increase in Vbeta 4+ CD8+ T cells. Similar abrogation of the Vbeta 4+ CD8+ response is seen following antibody-mediated depletion of the CD4+ subset, through the numbers of CD8+ CD62Llo cells are still significantly elevated. Virus-specific CD4+-T-cell frequencies are minimal in the CD40L-/- mice, and the Vbeta 4+ CD8+ population remains unexpanded. Apparently B-cell-CD4+-T-cell interactions play a part in the gamma HV-68 induction of both splenomegaly and non-MHC-restricted Vbeta 4+ CD8+-T-cell expansion.

* Corresponding author. Mailing address: Department of Immunology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105. Phone: (901) 495-3470. Fax: (901) 495-3107. E-mail: peter.doherty{at}stjude.org.

dagger Present address: Transduction Laboratories, Inc., Lexington, KY 40511.

Dagger Present address: Infectious Diseases, Parke-Davis Pharmaceutical Research, Ann Arbor, MI 48103.

Journal of Virology, November 1999, p. 9650-9654, Vol. 73, No. 11
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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