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Journal of Virology, October 1999, p. 8913-8916, Vol. 73, No. 10
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Divergent Requirements for the MAPKERK Signal Transduction Pathway during Initial Virus Infection of Quiescent Primary B Cells and Disruption of Epstein-Barr Virus Latency by Phorbol Esters

Mandy Fenton and Alison J. Sinclair*

School of Biological Sciences, University of Sussex, Brighton, East Sussex BN1 9QG, United Kingdom

Received 26 April 1999/Accepted 28 June 1999

Quiescent primary B lymphocytes and Epstein-Barr virus (EBV)-immortalized lymphoblastoid cell lines express components of the extracellular response kinase arm of the mitogen-activated protein kinase (MAPKERK) signal transduction pathway and transmit signals through the pathway when exposed to appropriate stimuli. Although the MAPKERK pathway is activated following infection with EBV, MAPK/ERK kinase (MEK1) activity is not required to drive the proliferation of infected cells. However, MEK1 contributes to EBV latency control.

* Corresponding author. Mailing address: School of Biological Sciences, University of Sussex, Brighton, East Sussex BN1 9QG, United Kingdom. Phone: 01273 678 194. Fax: 01273 678 433. E-mail: A.J.Sinclair{at}sussex.ac.uk.

Journal of Virology, October 1999, p. 8913-8916, Vol. 73, No. 10
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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