This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rimmelzwaan, G. F.
Right arrow Articles by Osterhaus, A. D. M. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rimmelzwaan, G. F.
Right arrow Articles by Osterhaus, A. D. M. E.

 Previous Article  |  Next Article 

Journal of Virology, October 1999, p. 8880-8883, Vol. 73, No. 10
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Inhibition of Influenza Virus Replication by Nitric Oxide

Guus F. Rimmelzwaan,* Marianne M. J. W. Baars, Pim de Lijster, Ron A. M. Fouchier, and Albert D. M. E. Osterhaus

National Influenza Center, Department of Virology, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands

Received 5 March 1999/Accepted 2 July 1999

Nitric oxide (NO) has been shown to contribute to the pathogenesis of influenza virus-induced pneumonia in mouse models. Here we show that replication of influenza A and B viruses in Mabin Darby canine kidney cells is severely impaired by the NO donor, S-nitroso-N-acetylpenicillamine. Reduction of productively infected cells and virus production proved to correlate with inhibition of viral RNA synthesis, indicating that NO affects an early step in the replication cycle of influenza viruses.

* Corresponding author. Mailing address: National Influenza Center, Department of Virology, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands. Phone: 31 10 4088066. Fax: 31 10 4089485. E-mail: rimmelzwaan{at}viro.fgg.eur.nl.

Journal of Virology, October 1999, p. 8880-8883, Vol. 73, No. 10
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • GeurtsvanKessel, C. H., Willart, M. A.M., van Rijt, L. S., Muskens, F., Kool, M., Baas, C., Thielemans, K., Bennett, C., Clausen, B. E., Hoogsteden, H. C., Osterhaus, A. D.M.E., Rimmelzwaan, G. F., Lambrecht, B. N. (2008). Clearance of influenza virus from the lung depends on migratory langerin+CD11b- but not plasmacytoid dendritic cells. JEM 205: 1621-1634 [Abstract] [Full Text]  
  • Akerstrom, S., Mousavi-Jazi, M., Klingstrom, J., Leijon, M., Lundkvist, A., Mirazimi, A. (2005). Nitric Oxide Inhibits the Replication Cycle of Severe Acute Respiratory Syndrome Coronavirus. J. Virol. 79: 1966-1969 [Abstract] [Full Text]  
  • Message, S. D., Johnston, S. L. (2004). Host defense function of the airway epithelium in health and disease: clinical background. J. Leukoc. Biol. 75: 5-17 [Abstract] [Full Text]  
  • Davis, I. C., Zajac, A. J., Nolte, K. B., Botten, J., Hjelle, B., Matalon, S. (2002). Elevated Generation of Reactive Oxygen/Nitrogen Species in Hantavirus Cardiopulmonary Syndrome. J. Virol. 76: 8347-8359 [Abstract] [Full Text]  
  • Klöcker, U., Schultz, U., Schaller, H., Protzer, U. (2000). Endotoxin Stimulates Liver Macrophages To Release Mediators That Inhibit an Early Step in Hepadnavirus Replication. J. Virol. 74: 5525-5533 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»