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Journal of Virology, October 1999, p. 8880-8883, Vol. 73, No. 10
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Inhibition of Influenza Virus Replication by Nitric Oxide

Guus F. Rimmelzwaan,* Marianne M. J. W. Baars, Pim de Lijster, Ron A. M. Fouchier, and Albert D. M. E. Osterhaus

National Influenza Center, Department of Virology, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands

Received 5 March 1999/Accepted 2 July 1999

Nitric oxide (NO) has been shown to contribute to the pathogenesis of influenza virus-induced pneumonia in mouse models. Here we show that replication of influenza A and B viruses in Mabin Darby canine kidney cells is severely impaired by the NO donor, S-nitroso-N-acetylpenicillamine. Reduction of productively infected cells and virus production proved to correlate with inhibition of viral RNA synthesis, indicating that NO affects an early step in the replication cycle of influenza viruses.

* Corresponding author. Mailing address: National Influenza Center, Department of Virology, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands. Phone: 31 10 4088066. Fax: 31 10 4089485. E-mail: rimmelzwaan{at}viro.fgg.eur.nl.

Journal of Virology, October 1999, p. 8880-8883, Vol. 73, No. 10
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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