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Journal of Virology, October 1999, p. 7994-8002, Vol. 73, No. 10
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Discovery of a New Endogenous Type C Retrovirus (FcEV) in Cats: Evidence for RD-114 Being an FcEV^Gag-Pol/Baboon Endogenous Virus BaEV^Env Recombinant

Antoinette C. van der Kuyl,^1,* John T. Dekker,¹ and Jaap Goudsmit²

Department of Human Retrovirology, Academic Medical Centre, 1105 AZ Amsterdam,¹ and Amsterdam Institute of Viral Genomics, 1105 BA Amsterdam, The Netherlands²

Received 29 March 1999/Accepted 17 June 1999

Analysis of a cat genomic DNA library showed that cats harbor a previously unrecognized endogenous type C retrovirus, whose env gene has homology to the murine Fv-4 resistance gene. This unique retrovirus, designated FcEV (Felis catus endogenous retrovirus), has a type C pol gene, closely related to the primate Papio cynocephalus endogenous virus (PcEV) pol, not overlapping the env gene, unlike in other type C retroviruses, and is presumably present in a higher copy number than RD-114. Phylogenetic analysis of FcEV and RD-114 fragments amplified from cat species and comparison with baboon endogenous virus (BaEV) fragments from monkeys suggested that RD-114 does not represent the cat strain of BaEV but is actually a new recombinant between FcEV type C genes and the env gene of BaEV. Although BaEV did appear to have infected an ancestor of the domestic cat lineage, it was a de novo recombinant that made its way into the cat germ line.

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^* Corresponding author. Mailing address: Department of Human Retrovirology, Academic Medical Centre, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands. Phone: 31 20 566 4522. Fax: 31 20 691 6531. E-mail: a.c.vanderkuyl{at}amc.uva.nl.

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Journal of Virology, October 1999, p. 7994-8002, Vol. 73, No. 10
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

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