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Journal of Virology, January 1999, p. 839-842, Vol. 73, No. 1
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Binding Specificity of Protein Phosphatase 2A Core Enzyme for Regulatory B Subunits and T Antigens

Ralf Ruediger, Katherine Fields, and Gernot Walter*

Department of Pathology, University of California at San Diego, La Jolla, California 92093-0612

Received 12 August 1998/Accepted 1 October 1998

The core enzyme of protein phosphatase 2A is composed of a regulatory subunit A and a catalytic subunit C. It is controlled by three types of regulatory B subunits (B, B', and B") and by tumor (T) antigens, which are unrelated by sequence but bind to overlapping regions on the A subunit. To find out whether the different B subunits and T antigens bind to identical or distinct amino acids of the A subunit, mutants were generated and their abilities to bind B subunits and T antigens were tested. We found that some amino acids are involved in the binding of all types of B subunits, whereas others are specifically involved in the binding of one or two types of B subunits. T-antigen-binding specificity does not correlate with that of a particular type of B subunit.

* Corresponding author. Mailing address: Department of Pathology, University of California at San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0612. Phone: (619) 534-1894. Fax: (619) 534-8942. E-mail: GWalter{at}ucsd.edu.

Journal of Virology, January 1999, p. 839-842, Vol. 73, No. 1
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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