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Journal of Virology, January 1999, p. 810-813, Vol. 73, No. 1
Infectious Diseases Laboratories, Institute
of Medical and Veterinary Science, Adelaide, South Australia 5000, Australia
Received 7 July 1998/Accepted 25 September 1998
Herpes simplex virus type 1 DNA isomerization was studied by using
a viral mutant, 5B8, lacking the unique SpeI site of its parent, SC16. In coinfected cells, SC16 genomic long segments flanked
5B8 genomes in all possible orientations with similar frequencies.
Thus, recombination between progeny of different replication templates
is sufficient to explain genomic isomerization.
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Herpes Simplex Virus Genome Isomerization: Origins of Adjacent
Long Segments in Concatemeric Viral DNA

and
*
Corresponding author. Mailing address: Infectious
Diseases Laboratories, Institute of Medical and Veterinary Science,
Frome Rd., Adelaide, South Australia 5000, Australia. Phone: 61 8 8222 3541. Fax: 61 8 8222 3538. E-mail:
tsimmons{at}webmedia.com.au.
Present address: Dept. of Microbiology and Immunology, Stanford
University School of Medicine, Stanford, CA 94305-5402.
Present address: Cantab Pharmaceuticals Research Ltd.,
Cambridge Science Park, Cambridge CB4 4GN, United Kingdom.
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