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Journal of Virology, January 1999, p. 810-813, Vol. 73, No. 1
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Herpes Simplex Virus Genome Isomerization: Origins of Adjacent Long Segments in Concatemeric Viral DNA

B. Slobedman,dagger X. Zhang,Dagger and A. Simmons*

Infectious Diseases Laboratories, Institute of Medical and Veterinary Science, Adelaide, South Australia 5000, Australia

Received 7 July 1998/Accepted 25 September 1998

Herpes simplex virus type 1 DNA isomerization was studied by using a viral mutant, 5B8, lacking the unique SpeI site of its parent, SC16. In coinfected cells, SC16 genomic long segments flanked 5B8 genomes in all possible orientations with similar frequencies. Thus, recombination between progeny of different replication templates is sufficient to explain genomic isomerization.

* Corresponding author. Mailing address: Infectious Diseases Laboratories, Institute of Medical and Veterinary Science, Frome Rd., Adelaide, South Australia 5000, Australia. Phone: 61 8 8222 3541. Fax: 61 8 8222 3538. E-mail: tsimmons{at}webmedia.com.au.

dagger Present address: Dept. of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305-5402.

Dagger Present address: Cantab Pharmaceuticals Research Ltd., Cambridge Science Park, Cambridge CB4 4GN, United Kingdom.

Journal of Virology, January 1999, p. 810-813, Vol. 73, No. 1
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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