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Journal of Virology, January 1999, p. 801-804, Vol. 73, No. 1
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

An Attenuated Variant of the GDVII Strain of Theiler's Virus Does Not Persist and Does Not Infect the White Matter of the Central Nervous System

Nadine Jarousse,dagger Ekaterina G. Viktorova,2 Evgeny V. Pilipenko,2 Vadim I. Agol,2 and Michel Brahic1,*

Unité des Virus Lents, ERS 572 CNRS, Institut Pasteur, 75724 Paris Cedex 15, France,1 and Institute of Poliomyelitis and Viral Encephalitides, Moscow Region 142782, Russia2

Received 10 July 1998/Accepted 23 September 1998

The DA strain of Theiler's virus causes a persistent and demyelinating infection of the white matter of spinal cord, whereas the GDVII strain causes a fatal gray-matter encephalomyelitis. Studies with recombinant viruses showed that this difference in phenotype is controlled mainly by the capsid. However, conflicting results regarding the existence of determinants of persistence in the capsid of the GDVII strain have been published. Here we show that a GDVII virus whose neurovirulence has been attenuated by an insertion in the 5' noncoding region does not persist in the central nervous systems of mice. Furthermore, this virus infects the gray matter efficiently, but not the white matter. These results confirm the absence of determinants of persistence in the GDVII capsid. They suggest that the DA capsid controls persistence by allowing the virus to infect cells in the white matter of the spinal cord.

* Corresponding author. Mailing address: Unité des Virus Lents, ERS 572 CNRS, Institut Pasteur, 75724 Paris Cedex 15, France. Phone: 33 1 45 68 87 70. Fax: 33 1 40 61 31 67. E-mail: mbrahic{at}pasteur.fr.

dagger Present address: Hormone Research Institute, University of California San Francisco, San Francisco, CA 94143-0534.

Journal of Virology, January 1999, p. 801-804, Vol. 73, No. 1
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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