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Journal of Virology, January 1999, p. 754-759, Vol. 73, No. 1
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Human Herpesvirus 6 Latently Infects Early Bone Marrow Progenitors In Vivo

Mario Luppi,1 Patrizia Barozzi,1 Christine Morris,2 Antonio Maiorana,3 Richard Garber,4 Goretta Bonacorsi,1 Amedea Donelli,1 Roberto Marasca,1 Antonio Tabilio,5 and Giuseppe Torelli1,*

Section of Hematology, Department of Medical Sciences,1 and Department of Pathology,3 University of Modena, Modena, and Clinical Hematology and Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia,5 Italy; Cytogenetic and Molecular Oncology Unit, Department of Pathology, Christchurch School of Medicine, Christchurch, New Zealand2; and PathoGenesis Corporation, Seattle, Washington4

Received 19 June 1998/Accepted 7 October 1998

We have studied the in vivo tropism of human herpesvirus 6 (HHV-6) for hemopoietic cells in patients with latent HHV-6 infection. Having used a variety of cell purification, molecular, cytogenetic, and immunocytochemical procedures, we report the first evidence that HHV-6 latently infects early bone marrow progenitor cells and that HHV-6 may be transmitted longitudinally to cells which differentiate along the committed pathways.

* Corresponding author. Mailing address: Department of Medical Sciences, Section of Hematology, Via del Pozzo 71, 41100 Modena, Italy. Phone: 39 59 424174. Fax: 39 59 424549.

Journal of Virology, January 1999, p. 754-759, Vol. 73, No. 1
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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