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Journal of Virology, January 1999, p. 601-607, Vol. 73, No. 1
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Asymptomatic Simian Immunodeficiency Virus Infection Decreases Blood CD4+ T Cells by Accumulating Recirculating Lymphocytes in the Lymphoid Tissuesdagger

Alan R. Schenkel, Hideo Uno, and C. David Pauza*

Department of Pathology and Laboratory Medicine and Wisconsin Regional Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin 53706

Received 6 August 1998/Accepted 13 October 1998

Declining blood CD4+ T-cell counts mark the progress of simian immunodeficiency virus (SIV) disease in macaques and model the consequences of untreated human immunodeficiency virus infection in humans. However, blood lymphocytes are only a fraction of the recirculating lymphocyte pool, and their numbers are affected by cell synthesis, cell depletion, and distribution among blood and lymphoid tissue compartments. Asymptomatic, SIV-infected macaques maintained constant and nearly normal numbers of recirculating lymphocytes despite the decline in CD4+ T-cell counts. Substantial depletion was detected only when blood CD4+ T-cell counts fell below 300/µl. In asymptomatic animals, changes in CD4+ T-cell distribution were more important than lymphocyte depletion for controlling the blood cell levels.

* Corresponding author. Mailing address: Department of Pathology, University of Wisconsin, 1300 University Ave., Madison, WI 53706. Phone: (608) 262-9147. Fax: (608) 262-9148. E-mail: cdpauza{at}facstaff.wisc.edu.

dagger Publication 38010 from the Wisconsin Regional Primate Research Center.

Journal of Virology, January 1999, p. 601-607, Vol. 73, No. 1
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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