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Journal of Virology, January 1999, p. 436-443, Vol. 73, No. 1
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Strong Human Immunodeficiency Virus (HIV)-Specific Cytotoxic T-Lymphocyte Activity in Sydney Blood Bank Cohort Patients Infected with nef-Defective HIV Type 1

Wayne B. Dyer,1,* Graham S. Ogg,2 Marie-Ange Demoitie,3 Xia Jin,3 Andrew F. Geczy,1 Sarah L. Rowland-Jones,2 Andrew J. McMichael,2 Douglas F. Nixon,3 and John S. Sullivan1

Australian Red Cross Blood Service-NSW, Sydney, New South Wales, Australia1; Institute of Molecular Medicine, Nuffield Department of Medicine, Oxford, United Kingdom2; and Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York3

Received 13 July 1998/Accepted 21 September 1998

Proposals for the use of live attenuated human immunodeficiency virus (HIV) type 1 (HIV-1) as a vaccine candidate in humans have been based on the protection afforded by attenuated simian immunodeficiency virus in the macaque model. Although it is not yet known if this strategy could succeed in humans, a study of the Sydney Blood Bank Cohort (SBBC), infected with an attenuated HIV-1 quasispecies with natural nef and nef/long terminal repeat deletions for up to 17 years, could provide insights into the long-term immunological consequences of living with an attenuated HIV-1 infection. In this study, HIV-specific cytoxic T-lymphocyte (CTL) responses in an SBBC donor and six recipients were examined over a 3-year period with enzyme-linked immunospot, tetrameric complex binding, direct CTL lysis, and CTL precursor level techniques. Strong HIV-specific CTL responses were detected in four of seven patients, including one patient with an undetectable viral load. Two of seven patients had weak CTL responses, and in one recipient, no HIV-specific CTLs were detected. High levels of circulating effector and memory HIV-specific CTLs can be maintained for prolonged periods in these patients despite very low viral loads.

* Corresponding author. Mailing address: Australian Red Cross Blood Service-NSW, 153 Clarence St., Sydney, NSW 2000, Australia. Phone: 61 2 9229 4557. Fax: 61 2 9229 4521. E-mail: wdyer{at}arcbs.redcross.org.au.

Journal of Virology, January 1999, p. 436-443, Vol. 73, No. 1
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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