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Journal of Virology, September 1998, p. 7688-7691, Vol. 72, No. 9
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Preactivation of B Lymphocytes Does Not Enhance Mouse Mammary Tumor Virus Infection

Daniela Finke,1 Laure Mortezavi,1 and Hans Acha-Orbea1,2,*

Ludwig Institute for Cancer Research, Lausanne Branch,1 and Institute for Biochemistry,2 University of Lausanne, 1066 Epalinges, Switzerland

Received 20 November 1997/Accepted 10 June 1998

We investigated whether mouse mammary tumor virus (MMTV) favors preactivated or naive B cells as targets for efficient infection. We have demonstrated previously that MMTV activates B cells upon infection. Here, we show that polyclonal activation of B cells leads instead to lower infection levels and attenuated superantigen-specific T-cell responses in vivo. This indicates that naive small resting B cells are the major targets of MMTV infection and that the activation induced by MMTV is sufficient to allow efficient infection.

* Corresponding author. Mailing address: Ludwig Institute for Cancer Research and Institute for Biochemistry, Lausanne Branch, University of Lausanne, 1066 Epalinges, Switzerland. Phone: 41-21-6925710. Fax: 41-21-6534474. E-mail: hacha{at}eliot.unil.ch.

Journal of Virology, September 1998, p. 7688-7691, Vol. 72, No. 9
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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