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Journal of Virology, September 1998, p. 7557-7562, Vol. 72, No. 9
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Replacement of Loop II of VP1 of the DA Strain with Loop II of the GDVII Strain of Theiler's Murine Encephalomyelitis Virus Alters Neurovirulence, Viral Persistence, and Demyelination

Yoshiaki Wada,1,dagger Ingeborg J. McCright,1 Frank G. Whitby,2 Ikuo Tsunoda,1 and Robert S. Fujinami1,*

Department of Neurology and Pathology1 and Department of Biochemistry,2 University of Utah, Salt Lake City, Utah 84132

Received 14 January 1998/Accepted 28 May 1998

Theiler's murine encephalomyelitis viruses, which are murine picornaviruses, can cause central nervous system inflammatory disease. To study the role of loop II in capsid protein VP1, two mutant viruses of strain DA in which DA loop II amino acids were replaced with strain GDVII amino acids were constructed. Infection of mice with the two mutant viruses led to dramatically different patterns of disease.

* Corresponding author. Mailing address: Department of Neurology, University of Utah, 3R330 School of Medicine, 50 North Medical Dr., Salt Lake City, UT 84132. Phone: (801) 585-3305. Fax: (801) 585-3311. E-mail: Robert.Fujinami{at}hsc.utah.edu.

dagger Present address: Department of Neurology, Tokyo Medical & Dental University, Bunkyo-Ku, Tokyo 113, Japan.

Journal of Virology, September 1998, p. 7557-7562, Vol. 72, No. 9
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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Copyright © 1998 by the American Society for Microbiology. All rights reserved.