This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wada, Y.
Right arrow Articles by Fujinami, R. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wada, Y.
Right arrow Articles by Fujinami, R. S.

 Previous Article  |  Next Article 

Journal of Virology, September 1998, p. 7557-7562, Vol. 72, No. 9
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Replacement of Loop II of VP1 of the DA Strain with Loop II of the GDVII Strain of Theiler's Murine Encephalomyelitis Virus Alters Neurovirulence, Viral Persistence, and Demyelination

Yoshiaki Wada,1,dagger Ingeborg J. McCright,1 Frank G. Whitby,2 Ikuo Tsunoda,1 and Robert S. Fujinami1,*

Department of Neurology and Pathology1 and Department of Biochemistry,2 University of Utah, Salt Lake City, Utah 84132

Received 14 January 1998/Accepted 28 May 1998

Theiler's murine encephalomyelitis viruses, which are murine picornaviruses, can cause central nervous system inflammatory disease. To study the role of loop II in capsid protein VP1, two mutant viruses of strain DA in which DA loop II amino acids were replaced with strain GDVII amino acids were constructed. Infection of mice with the two mutant viruses led to dramatically different patterns of disease.

* Corresponding author. Mailing address: Department of Neurology, University of Utah, 3R330 School of Medicine, 50 North Medical Dr., Salt Lake City, UT 84132. Phone: (801) 585-3305. Fax: (801) 585-3311. E-mail: Robert.Fujinami{at}hsc.utah.edu.

dagger Present address: Department of Neurology, Tokyo Medical & Dental University, Bunkyo-Ku, Tokyo 113, Japan.

Journal of Virology, September 1998, p. 7557-7562, Vol. 72, No. 9
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Blinkova, O., Kapoor, A., Victoria, J., Jones, M., Wolfe, N., Naeem, A., Shaukat, S., Sharif, S., Alam, M. M., Angez, M., Zaidi, S., Delwart, E. L. (2009). Cardioviruses Are Genetically Diverse and Cause Common Enteric Infections in South Asian Children. J. Virol. 83: 4631-4641 [Abstract] [Full Text]  
  • Tsunoda, I., Wada, Y., Libbey, J. E., Cannon, T. S., Whitby, F. G., Fujinami, R. S. (2001). Prolonged Gray Matter Disease without Demyelination Caused by Theiler's Murine Encephalomyelitis Virus with a Mutation in VP2 Puff B. J. Virol. 75: 7494-7505 [Abstract] [Full Text]  
  • McCright, I. J., Tsunoda, I., Whitby, F. G., Fujinami, R. S. (1999). Theiler's Viruses with Mutations in Loop I of VP1 Lead to Altered Tropism and Pathogenesis. J. Virol. 73: 2814-2824 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»