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J Virol, August 1998, p. 6907-6910, Vol. 72, No. 8
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Recombinant Sindbis Viruses Expressing a Cytotoxic T-Lymphocyte Epitope of a Malaria Parasite or of Influenza Virus Elicit Protection against the Corresponding Pathogen in Mice

Moriya Tsuji,1 Cornelia C. Bergmann,2 Yoshiko Takita-Sonoda,1 Ken-Ichiro Murata,1 Elaine G. Rodrigues,1 Ruth S. Nussenzweig,1 and Fidel Zavala1,*

Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York 10010,1 and Department of Neurology, University of Southern California, Los Angeles, California 900332

Received 7 January 1998/Accepted 11 May 1998

Subcutaneous administration in mice of recombinant Sindbis viruses expressing a class I major histocompatibility complex-restricted 9-mer epitope of the Plasmodium yoelii circumsporozoite protein or the nucleoprotein of influenza virus induces a large epitope-specific CD8+ T-cell response. This immunization also elicits a high degree of protection against infection with malaria or influenza A virus.

* Corresponding author. Mailing address: Department of Medical and Molecular Parasitology, New York University School of Medicine, 341 E. 25th St., New York, NY 10010. Phone: (212) 263-6760. Fax: (212) 263-8116. E-mail: fz5{at}is2.nyu.edu.

J Virol, August 1998, p. 6907-6910, Vol. 72, No. 8
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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