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J Virol, August 1998, p. 6898-6901, Vol. 72, No. 8
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Binding of Murine Leukemia Virus Gag Polyproteins to KIF4, a Microtubule-Based Motor Protein

Wankee Kim,1,2 Yao Tang,1 Yasushi Okada,3 Ted A. Torrey,1 Sisir K. Chattopadhyay,1 Michael Pfleiderer,4 Falko G. Falkner,4 Friedrich Dorner,4 Wonja Choi,5 Nobutaka Hirokawa,3 and Herbert C. Morse III1,*

Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 208921; Department of Cell Biology and Anatomy, Graduate School, University of Tokyo, Tokyo, Japan3; IMMUNO AG, Vienna, Austria4; and Molecular Biology Laboratory, Institute for Medical Sciences, Ajou University, Kyongki,2 and Ewha Women's University, Seoul,5 Korea

Received 29 October 1997/Accepted 12 May 1998

A cDNA clone encoding a cellular protein that interacts with murine leukemia virus (MuLV) Gag proteins was isolated from a T-cell lymphoma library. The sequence of the clone is identical to the C terminus of a cellular protein, KIF4, a microtubule-associated motor protein that belongs to the kinesin superfamily. KIF4-MuLV Gag associations have been detected in vitro and in vivo in mammalian cells. We suggest that KIF4 could be involved in Gag polyprotein translocation from the cytoplasm to the cell membrane.

* Corresponding author. Mailing address: LIP, NIAID, NIH, 7 Center Dr., Bethesda, MD 20892-0760. Phone: (301) 496-6379. Fax: (301) 402-0077. E-mail: hmorse{at}atlas.niaid.nih.gov.

J Virol, August 1998, p. 6898-6901, Vol. 72, No. 8
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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