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J Virol, July 1998, p. 6233-6236, Vol. 72, No. 7
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

The Agnogene of the Human Polyomavirus BK Is Expressed

Christine Hanssen Rinaldo, Terje Traavik,* and Allan Heydagger

Department of Virology, Institute of Medical Biology, University of Tromsø, N-9037 Tromsø, Norway

Received 15 December 1997/Accepted 13 April 1998

Primate polyomavirus genomes all contain an open reading frame at the 5' end of the late coding region called the agnogene. A simian virus 40 agnoprotein with unknown functions has previously been demonstrated. We now show that a BK virus agnoprotein appears in the perinuclear area and cytoplasm late in the infectious cycle. It is phosphorylated in vivo and coimmunoprecipitates with a subset of host cell proteins.

* Corresponding author. Mailing address: Department of Virology, Institute of Medical Biology, University of Tromsø, N-9037 Tromsø, Norway. Phone: 47 77 64 46 21. Fax: 47 77 64 53 50. E-mail: terjet{at}fagmed.uit.no.

dagger Present address: BresaGen Limited, Adelaide 5000, South Australia, Australia.

J Virol, July 1998, p. 6233-6236, Vol. 72, No. 7
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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