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J Virol, July 1998, p. 6190-6194, Vol. 72, No. 7
Division of Basic Sciences, Fred Hutchinson
Cancer Research Center, Seattle, Washington
98109,1 and
Department of
Microbiology, University of Washington, Seattle, Washington
981952
Received 15 October 1997/Accepted 26 March 1998
We have defined a 160-nucleotide region, M
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
A Minimal Avian Retroviral Packaging Sequence Has a
Complex Structure
, from the 5' leader
region of the Rous sarcoma virus genome that is sufficient to direct
the packaging of a heterologous RNA. M
contains the putative O3 stem
structure that has previously been shown, and that has been confirmed
in this study, to be important for the efficient packaging of avian
leukosis-sarcoma virus RNA. Analyses of several O3 stem mutants
revealed that other regions within M
can interfere with the proper
folding of altered sequences which are predicted to form a wild-type O3
stem.
*
Corresponding author. Mailing address: Division of
Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA
98109-1024. Phone: (206) 667-4442. Fax: (206) 667-5939. E-mail:
mlinial{at}fred.fhcrc.org.
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