Previous Article | Next Article 
J Virol, July 1998, p. 6113-6118, Vol. 72, No. 7
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
The Orphan Seven-Transmembrane Receptor Apj
Supports the Entry of Primary T-Cell-Line-Tropic and Dualtropic Human
Immunodeficiency Virus Type 1
Hyeryun
Choe,1,2
Michael
Farzan,1,2
Miriam
Konkel,1,2
Kathleen
Martin,3,4
Ying
Sun,1,2
Luisa
Marcon,1,2
Mark
Cayabyab,1,2,3
Michael
Berman,2
Martin E.
Dorf,2
Norma
Gerard,3,4
Craig
Gerard,3,4 and
Joseph
Sodroski1,2,5,*
Division of Human Retrovirology, Dana-Farber
Cancer Institute,1
Department of
Pathology, Harvard Medical School,2
Perlmutter Laboratory, Children's
Hospital,3
Departments of Medicine and
Pediatrics, Beth Israel Hospital and Harvard Medical
School,4 and
Department of Immunology
and Infectious Diseases, Harvard School of Public
Health,5 Boston, Massachusetts 02115
Received 16 January 1998/Accepted 6 April 1998
Human immunodeficiency virus type 1 (HIV-1) enters target cells by
sequential binding to CD4 and specific seven-transmembrane-segment (7TMS) coreceptors. Viruses use the chemokine receptor CCR5 as a
coreceptor in the early, asymptomatic stages of HIV-1 infection but can
adapt to the use of other receptors such as CXCR4 and CCR3 as the
infection proceeds. Here we identify one such coreceptor, Apj, which
supported the efficient entry of several primary T-cell-line tropic
(T-tropic) and dualtropic HIV-1 isolates and the simian immunodeficiency virus SIVmac316. Another 7TMS protein, CCR9, supported
the less efficient entry of one primary T-tropic isolate. mRNAs for
both receptors were present in phytohemagglutinin- and interleukin-2-activated peripheral blood mononuclear cells. Apj and
CCR9 share with other coreceptors for HIV-1 and SIV an N-terminal region rich in aromatic and acidic residues. These results highlight properties common to 7TMS proteins that can function as HIV-1 coreceptors, and they may contribute to an understanding of viral evolution in infected individuals.
*
Corresponding author. Mailing address: JFB 824, Dana-Farber Cancer Institute, 44 Binney St., Boston, MA 02115. Phone:
(617) 632-3371. Fax: (617) 632-4338. E-mail:
joseph_sodroski{at}dfci.harvard.edu.
J Virol, July 1998, p. 6113-6118, Vol. 72, No. 7
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
This article has been cited by other articles:
-
Nedellec, R., Coetzer, M., Shimizu, N., Hoshino, H., Polonis, V. R., Morris, L., Martensson, U. E. A., Binley, J., Overbaugh, J., Mosier, D. E.
(2009). Virus Entry via the Alternative Coreceptors CCR3 and FPRL1 Differs by Human Immunodeficiency Virus Type 1 Subtype. J. Virol.
83: 8353-8363
[Abstract]
[Full Text]
-
Agrawal, L., Maxwell, C. R., Peters, P. J., Clapham, P. R., Liu, S. M., Mackay, C. R., Strayer, D. S.
(2009). Complexity in human immunodeficiency virus type 1 (HIV-1) co-receptor usage: roles of CCR3 and CCR5 in HIV-1 infection of monocyte-derived macrophages and brain microglia. J. Gen. Virol.
90: 710-722
[Abstract]
[Full Text]
-
Shimizu, N., Tanaka, A., Oue, A., Mori, T., Apichartpiyakul, C., Hoshino, H.
(2008). A short amino acid sequence containing tyrosine in the N-terminal region of G protein-coupled receptors is critical for their potential use as co-receptors for human and simian immunodeficiency viruses. J. Gen. Virol.
89: 3126-3136
[Abstract]
[Full Text]
-
Masri, B., Morin, N., Pedebernade, L., Knibiehler, B., Audigier, Y.
(2006). The Apelin Receptor Is Coupled to Gi1 or Gi2 Protein and Is Differentially Desensitized by Apelin Fragments. J. Biol. Chem.
281: 18317-18326
[Abstract]
[Full Text]
-
Gray, L., Churchill, M. J., Keane, N., Sterjovski, J., Ellett, A. M., Purcell, D. F. J., Poumbourios, P., Kol, C., Wang, B., Saksena, N. K., Wesselingh, S. L., Price, P., French, M., Gabuzda, D., Gorry, P. R.
(2006). Genetic and Functional Analysis of R5X4 Human Immunodeficiency Virus Type 1 Envelope Glycoproteins Derived from Two Individuals Homozygous for the CCR5{Delta}32 Allele.. J. Virol.
80: 3684-3691
[Abstract]
[Full Text]
-
Crowley, S., Gurley, S., Oliverio, M., Pazmino, A., Griffiths, R, Flannery, P., Spurney, R., Kim, H-S, Smithies, O, Le, T., Coffman, T., Boucher, J, Masri, B, Daviaud, D, Gesta, S, Guigne, C, Mazzucotelli, A, Castan-Laurell, I, Tack, I, Knibiehler, B, Carpene, C, Audigier, Y, Saulnier-Blache, J., Valet, P, Engeli, S, Bohnke, J, Gorzelniak, K, Janke, J, Schling, P, Bader, M, Luft, F, Sharma, A.
(2005). Is the Kidney Always the Cause of Hypertension?: Distinct Roles for the Kidney and Systemic Tissues in Blood Pressure Regulation by the Renin-Angiotensin System. J Clin Invest 115: 1092-1099, 2005. J. Am. Soc. Nephrol.
16: 1525-1532
[Full Text]
-
Blaak, H., Boers, P. H. M., Gruters, R. A., Schuitemaker, H., van der Ende, M. E., Osterhaus, A. D. M. E.
(2005). CCR5, GPR15, and CXCR6 Are Major Coreceptors of Human Immunodeficiency Virus Type 2 Variants Isolated from Individuals with and without Plasma Viremia. J. Virol.
79: 1686-1700
[Abstract]
[Full Text]
-
Lee, D. K., Lanca, A. J., Cheng, R., Nguyen, T., Ji, X. D., Gobeil, F. Jr., Chemtob, S., George, Susan. R., O'Dowd, B. F.
(2004). Agonist-independent Nuclear Localization of the Apelin, Angiotensin AT1, and Bradykinin B2 Receptors. J. Biol. Chem.
279: 7901-7908
[Abstract]
[Full Text]
-
Forte, S., Harmon, M.-E., Pineda, M. J., Overbaugh, J.
(2003). Early- and Intermediate-Stage Variants of Simian Immunodeficiency Virus Replicate Efficiently in Cells Lacking CCR5. J. Virol.
77: 9723-9727
[Abstract]
[Full Text]
-
Willey, S. J., Reeves, J. D., Hudson, R., Miyake, K., Dejucq, N., Schols, D., Clercq, E. D., Bell, J., McKnight, A., Clapham, P. R.
(2003). Identification of a Subset of Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus Strains Able To Exploit an Alternative Coreceptor on Untransformed Human Brain and Lymphoid Cells. J. Virol.
77: 6138-6152
[Abstract]
[Full Text]
-
Farzan, M., Chung, S., Li, W., Vasilieva, N., Wright, P. L., Schnitzler, C. E., Marchione, R. J., Gerard, C., Gerard, N. P., Sodroski, J., Choe, H.
(2002). Tyrosine-sulfated Peptides Functionally Reconstitute a CCR5 Variant Lacking a Critical Amino-terminal Region. J. Biol. Chem.
277: 40397-40402
[Abstract]
[Full Text]
-
Farzan, M., Babcock, G. J., Vasilieva, N., Wright, P. L., Kiprilov, E., Mirzabekov, T., Choe, H.
(2002). The Role of Post-translational Modifications of the CXCR4 Amino Terminus in Stromal-derived Factor 1alpha Association and HIV-1 Entry. J. Biol. Chem.
277: 29484-29489
[Abstract]
[Full Text]
-
Clapham, P. R., McKnight, A.
(2002). Cell surface receptors, virus entry and tropism of primate lentiviruses. J. Gen. Virol.
83: 1809-1829
[Abstract]
[Full Text]
-
Zhou, N., Luo, Z., Luo, J., Fan, X., Cayabyab, M., Hiraoka, M., Liu, D., Han, X., Pesavento, J., Dong, C.-Z., Wang, Y., An, J., Kaji, H., Sodroski, J. G., Huang, Z.
(2002). Exploring the Stereochemistry of CXCR4-Peptide Recognition and Inhibiting HIV-1 Entry with D-Peptides Derived from Chemokines. J. Biol. Chem.
277: 17476-17485
[Abstract]
[Full Text]
-
Naif, H. M., Cunningham, A. L., Alali, M., Li, S., Nasr, N., Buhler, M. M., Schols, D., de Clercq, E., Stewart, G.
(2002). A Human Immunodeficiency Virus Type 1 Isolate from an Infected Person Homozygous for CCR5{Delta}32 Exhibits Dual Tropism by Infecting Macrophages and MT2 Cells via CXCR4. J. Virol.
76: 3114-3124
[Abstract]
[Full Text]
-
Gorry, P. R., Bristol, G., Zack, J. A., Ritola, K., Swanstrom, R., Birch, C. J., Bell, J. E., Bannert, N., Crawford, K., Wang, H., Schols, D., De Clercq, E., Kunstman, K., Wolinsky, S. M., Gabuzda, D.
(2001). Macrophage Tropism of Human Immunodeficiency Virus Type 1 Isolates from Brain and Lymphoid Tissues Predicts Neurotropism Independent of Coreceptor Specificity. J. Virol.
75: 10073-10089
[Abstract]
[Full Text]
-
Sabbe, R., Picchio, G. R., Pastore, C., Chaloin, O., Hartley, O., Offord, R., Mosier, D. E.
(2001). Donor- and Ligand-Dependent Differences in C-C Chemokine Receptor 5 Reexpression. J. Virol.
75: 661-671
[Abstract]
[Full Text]
-
Cayabyab, M., Hinuma, S., Farzan, M., Choe, H., Fukusumi, S., Kitada, C., Nishizawa, N., Hosoya, M., Nishimura, O., Messele, T., Pollakis, G., Goudsmit, J., Fujino, M., Sodroski, J.
(2000). Apelin, the Natural Ligand of the Orphan Seven-Transmembrane Receptor APJ, Inhibits Human Immunodeficiency Virus Type 1 Entry. J. Virol.
74: 11972-11976
[Abstract]
[Full Text]
-
Bannert, N., Schenten, D., Craig, S., Sodroski, J.
(2000). The Level of CD4 Expression Limits Infection of Primary Rhesus Monkey Macrophages by a T-Tropic Simian Immunodeficiency Virus and Macrophagetropic Human Immunodeficiency Viruses. J. Virol.
74: 10984-10993
[Abstract]
[Full Text]
-
Dejucq, N.
(2000). HIV-1 replication in CD4+ T cell lines: the effects of adaptation on co-receptor use, tropism, and accessory gene function. J. Leukoc. Biol.
68: 331-337
[Abstract]
[Full Text]
-
Zhang, Y.-j., Lou, B., Lal, R. B., Gettie, A., Marx, P. A., Moore, J. P.
(2000). Use of Inhibitors To Evaluate Coreceptor Usage by Simian and Simian/Human Immunodeficiency Viruses and Human Immunodeficiency Virus Type 2 in Primary Cells. J. Virol.
74: 6893-6910
[Abstract]
[Full Text]
-
Sharron, M., Pohlmann, S., Price, K., Lolis, E., Tsang, M., Kirchhoff, F., Doms, R. W., Lee, B.
(2000). Expression and coreceptor activity of STRL33/Bonzo on primary peripheral blood lymphocytes. Blood
96: 41-49
[Abstract]
[Full Text]
-
Pöhlmann, S., Lee, B., Meister, S., Krumbiegel, M., Leslie, G., Doms, R. W., Kirchhoff, F.
(2000). Simian Immunodeficiency Virus Utilizes Human and Sooty Mangabey but Not Rhesus Macaque STRL33 for Efficient Entry. J. Virol.
74: 5075-5082
[Abstract]
[Full Text]
-
Scoggins, R. M., Taylor, J. R. Jr., Patrie, J., van't Wout, A. B., Schuitemaker, H., Camerini, D.
(2000). Pathogenesis of Primary R5 Human Immunodeficiency Virus Type 1 Clones in SCID-hu Mice. J. Virol.
74: 3205-3216
[Abstract]
[Full Text]
-
Murphy, P. M., Baggiolini, M., Charo, I. F., Hebert, C. A., Horuk, R., Matsushima, K., Miller, L. H., Oppenheim, J. J., Power, C. A.
(2000). International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors. Pharmacol. Rev.
52: 145-176
[Abstract]
[Full Text]
-
Schramm, B., Penn, M. L., Speck, R. F., Chan, S. Y., De Clercq, E., Schols, D., Connor, R. I., Goldsmith, M. A.
(2000). Viral Entry through CXCR4 Is a Pathogenic Factor and Therapeutic Target in Human Immunodeficiency Virus Type 1 Disease. J. Virol.
74: 184-192
[Abstract]
[Full Text]
-
Shimizu, N., Soda, Y., Kanbe, K., Liu, H.-y., Mukai, R., Kitamura, T., Hoshino, H.
(2000). A Putative G Protein-Coupled Receptor, RDC1, Is a Novel Coreceptor for Human and Simian Immunodeficiency Viruses. J. Virol.
74: 619-626
[Abstract]
[Full Text]
-
Murakami, T., Zhang, T.-Y., Koyanagi, Y., Tanaka, Y., Kim, J., Suzuki, Y., Minoguchi, S., Tamamura, H., Waki, M., Matsumoto, A., Fujii, N., Shida, H., Hoxie, J. A., Peiper, S. C., Yamamoto, N.
(1999). Inhibitory Mechanism of the CXCR4 Antagonist T22 against Human Immunodeficiency Virus Type 1 Infection. J. Virol.
73: 7489-7496
[Abstract]
[Full Text]
-
Singh, A., Besson, G., Mobasher, A., Collman, R. G.
(1999). Patterns of Chemokine Receptor Fusion Cofactor Utilization by Human Immunodeficiency Virus Type 1 Variants from the Lungs and Blood. J. Virol.
73: 6680-6690
[Abstract]
[Full Text]
-
Dumonceaux, J., Chanel, C., Valente, S., Quivet, L., Briand, P., Hazan, U.
(1999). Mutations in the env gene of human immunodeficiency virus type 1 NDK isolates and the use of African green monkey CXCR4 as a co-receptor in COS-7 cells. J. Gen. Virol.
80: 1975-1982
[Abstract]
[Full Text]
-
Blanpain, C., Lee, B., Vakili, J., Doranz, B. J., Govaerts, C., Migeotte, I., Sharron, M., Dupriez, V., Vassart, G., Doms, R. W., Parmentier, M.
(1999). Extracellular Cysteines of CCR5 Are Required for Chemokine Binding, but Dispensable for HIV-1 Coreceptor Activity. J. Biol. Chem.
274: 18902-18908
[Abstract]
[Full Text]
-
Schenten, D., Marcon, L., Karlsson, G. B., Parolin, C., Kodama, T., Gerard, N., Sodroski, J.
(1999). Effects of Soluble CD4 on Simian Immunodeficiency Virus Infection of CD4-Positive and CD4-Negative Cells. J. Virol.
73: 5373-5380
[Abstract]
[Full Text]
-
Howard, O. M. Z., Shirakawa, A.-K., Turpin, J. A., Maynard, A., Tobin, G. J., Carrington, M., Oppenheim, J. J., Dean, M.
(1999). Naturally Occurring CCR5 Extracellular and Transmembrane Domain Variants Affect HIV-1 Co-receptor and Ligand Binding Function. J. Biol. Chem.
274: 16228-16234
[Abstract]
[Full Text]
-
Shimizu, N., Soda, Y., Kanbe, K., Liu, H.-Y., Jinno, A., Kitamura, T., Hoshino, H.
(1999). An Orphan G Protein-Coupled Receptor, GPR1, Acts as a Coreceptor To Allow Replication of Human Immunodeficiency Virus Types 1 and 2 in Brain-Derived Cells. J. Virol.
73: 5231-5239
[Abstract]
[Full Text]
-
Mosier, D. E., Picchio, G. R., Gulizia, R. J., Sabbe, R., Poignard, P., Picard, L., Offord, R. E., Thompson, D. A., Wilken, J.
(1999). Highly Potent RANTES Analogues either Prevent CCR5-Using Human Immunodeficiency Virus Type 1 Infection In Vivo or Rapidly Select for CXCR4-Using Variants. J. Virol.
73: 3544-3550
[Abstract]
[Full Text]
-
Edinger, A. L., Blanpain, C., Kunstman, K. J., Wolinsky, S. M., Parmentier, M., Doms, R. W.
(1999). Functional Dissection of CCR5 Coreceptor Function through the Use of CD4-Independent Simian Immunodeficiency Virus Strains. J. Virol.
73: 4062-4073
[Abstract]
[Full Text]
-
Doranz, B. J., Orsini, M. J., Turner, J. D., Hoffman, T. L., Berson, J. F., Hoxie, J. A., Peiper, S. C., Brass, L. F., Doms, R. W.
(1999). Identification of CXCR4 Domains That Support Coreceptor and Chemokine Receptor Functions. J. Virol.
73: 2752-2761
[Abstract]
[Full Text]
-
Zhang, Y.-j., Moore, J. P.
(1999). Will Multiple Coreceptors Need To Be Targeted by Inhibitors of Human Immunodeficiency Virus Type 1 Entry?. J. Virol.
73: 3443-3448
[Abstract]
[Full Text]
-
Chan, S. Y., Speck, R. F., Power, C., Gaffen, S. L., Chesebro, B., Goldsmith, M. A.
(1999). V3 Recombinants Indicate a Central Role for CCR5 as a Coreceptor in Tissue Infection by Human Immunodeficiency Virus Type 1. J. Virol.
73: 2350-2358
[Abstract]
[Full Text]
-
Kimata, J. T., Gosink, J. J., KewalRamani, V. N., Rudensey, L. M., Littman, D. R., Overbaugh, J.
(1999). Coreceptor Specificity of Temporal Variants of Simian Immunodeficiency Virus Mne. J. Virol.
73: 1655-1660
[Abstract]
[Full Text]
-
Albright, A. V., Shieh, J. T. C., Itoh, T., Lee, B., Pleasure, D., O'Connor, M. J., Doms, R. W., Gonzalez-Scarano, F.
(1999). Microglia Express CCR5, CXCR4, and CCR3, but of These, CCR5 Is the Principal Coreceptor for Human Immunodeficiency Virus Type 1 Dementia Isolates. J. Virol.
73: 205-213
[Abstract]
[Full Text]
-
Zhang, Y.-j., Dragic, T., Cao, Y., Kostrikis, L., Kwon, D. S., Littman, D. R., KewalRamani, V. N., Moore, J. P.
(1998). Use of Coreceptors Other Than CCR5 by Non-Syncytium-Inducing Adult and Pediatric Isolates of Human Immunodeficiency Virus Type 1 Is Rare In Vitro. J. Virol.
72: 9337-9344
[Abstract]
[Full Text]
-
Miyagi, T., Chuang, L. F., Doi, R. H., Carlos, M. P., Torres, J. V., Chuang, R. Y.
(2000). Morphine Induces Gene Expression of CCR5 in Human CEM x174 Lymphocytes. J. Biol. Chem.
275: 31305-31310
[Abstract]
[Full Text]
-
Farzan, M., Vasilieva, N., Schnitzler, C. E., Chung, S., Robinson, J., Gerard, N. P., Gerard, C., Choe, H., Sodroski, J.
(2000). A Tyrosine-sulfated Peptide Based on the N Terminus of CCR5 Interacts with a CD4-enhanced Epitope of the HIV-1 gp120 Envelope Glycoprotein and Inhibits HIV-1 Entry. J. Biol. Chem.
275: 33516-33521
[Abstract]
[Full Text]
-
Hosoya, M., Kawamata, Y., Fukusumi, S., Fujii, R., Habata, Y., Hinuma, S., Kitada, C., Honda, S., Kurokawa, T., Onda, H., Nishimura, O., Fujino, M.
(2000). Molecular and Functional Characteristics of APJ. TISSUE DISTRIBUTION OF mRNA AND INTERACTION WITH THE ENDOGENOUS LIGAND APELIN. J. Biol. Chem.
275: 21061-21067
[Abstract]
[Full Text]