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J Virol, July 1998, p. 5797-5801, Vol. 72, No. 7
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

The Interleukin-17 Gene of Herpesvirus Saimiri

Andrea Knappe,1 Christian Hiller,1 Henk Niphuis,2 François Fossiez,3 Mathias Thurau,1 Sabine Wittmann,1 Eva-Maria Kuhn,2 Serge Lebecque,3 Jacques Banchereau,3,dagger Brigitte Rosenwirth,2 Bernhard Fleckenstein,1 Jonathan Heeney,2 and Helmut Fickenscher1,*

Institut für Klinische und Molekulare Virologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, D-91054 Erlangen, Germany1; Departments of Virology and Pathology, Biomedical Primate Research Centre, NL-2280 GH Rijswijk, The Netherlands2; and Schering-Plough Laboratoire de Recherches Immunologiques, F-69571 Dardilly, France3

Received 10 February 1998/Accepted 3 April 1998

In comparison to wild-type herpesvirus saimiri, viral interleukin-17 gene knockout mutants have unaltered behavior regarding viral replication, T-cell transformation in vitro, and pathogenicity in cottontop tamarins. Thus, this gene is not required for T-cell lymphoma induction but may contribute to apathogenic viral persistence in the natural host, the squirrel monkey.

* Corresponding author. Mailing address: Institut für Klinische und Molekulare Virologie, Friedrich-Alexander-Universität Erlangen- Nürnberg, Schlossgarten 4, D-91054 Erlangen, Germany. Phone: 49-9131-85-3786. Fax: 49-9131-85-6493. E-mail: helmutfr{at}viro.med.uni-erlangen.de.

dagger Present address: Baylor Institute for Immunology Research, Sammons Cancer Center, Dallas, TX 75246.

J Virol, July 1998, p. 5797-5801, Vol. 72, No. 7
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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