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J Virol, June 1998, p. 5276-5278, Vol. 72, No. 6
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
Polarized Budding of Measles Virus Is Not
Determined by Viral Surface Glycoproteins
A.
Maisner,1
H.-D.
Klenk,1 and
G.
Herrler1,2,*
Institut für Virologie,
Philipps-Universität Marburg, 35037 Marburg,1 and
Institut für
Virologie, Tierärztliche Hochschule Hannover, 30559 Hannover,2 Germany
Received 19 December 1997/Accepted 10 March 1998
For viruses that mature by a budding process, the envelope
glycoproteins are considered the major determinants for the site of
virus release from polarized epithelial cells. Viruses are usually
released from that membrane domain where the viral surface glycoproteins are transported to. We here report that measles virus has
developed a different maturation strategy. Measles virus was found to
be released from the apical membrane domain of polarized epithelial
cells, though the surface glycoproteins H and F were transported in a
nonpolarized fashion and to the basolateral membrane domain,
respectively.
*
Corresponding author. Mailing address: Institut
für Virologie, Tierärztliche Hochschule Hannover,
Bünteweg 17, 30559 Hannover, Germany. Phone:
49-511-953-8857. Fax: 49-511-953-8898. E-mail: herrler{at}viro.tiho-hannover.de.
J Virol, June 1998, p. 5276-5278, Vol. 72, No. 6
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
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