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J Virol, June 1998, p. 5256-5261, Vol. 72, No. 6
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Isolation and Propagation of Human Papillomavirus Type 16 in Human Xenografts Implanted in the Severe Combined Immunodeficiency Mouse

William Bonnez,1,* Carrie DaRin,1 Christine Borkhuis,1 Karen de Mesy Jensen,2 Richard C. Reichman,1 and Robert C. Rose1

Departments of Medicine1 and Pathology,2 University of Rochester School of Medicine and Dentistry, Rochester, New York 14642

Received 29 October 1997/Accepted 13 February 1998

We report the isolation and propagation of human papillomavirus type 16, the main agent of cervical cancer, using human foreskin fragments implanted in severe combined immunodeficiency mice. The infection produced viral particles, and with each passage of the virus it caused lesions identical to intraepithelial neoplasia, the precursor to carcinoma.

* Corresponding author. Mailing address: Infectious Diseases Unit, Box 689, University of Rochester Medical Center, 601 Elmwood Ave., Rochester, NY 14642. Phone: (716) 275-5871. Fax: (716) 442-9328. E-mail: william_bonnez{at}medicine.rochester.edu.

J Virol, June 1998, p. 5256-5261, Vol. 72, No. 6
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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