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J Virol, June 1998, p. 5239-5244, Vol. 72, No. 6
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Rabbit Genital Tissue Is Susceptible to Infection by Rabbit Oral Papillomavirus: an Animal Model for a Genital Tissue-Targeting Papillomavirus

Stephen B. Harvey,1 Nancy M. Cladel,2 Lynn R. Budgeon,2 Patricia A. Welsh,2 James W. Griffith,1 C. Max Lang,1 and Neil D. Christensen2,3,*

Department of Comparative Medicine,1 The Jake Gittlen Cancer Research Institute,2 and Department of Microbiology and Immunology,3 The Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033

Received 13 November 1997/Accepted 6 March 1998

Rabbit oral papillomavirus (ROPV) is a mucosatropic papillomavirus which naturally infects oral mucosal sites of domestic rabbits. In this study, we tested the hypothesis that rabbit genital mucosa is also susceptible to ROPV infection by using the athymic mouse xenograft system and adult immunocompetent rabbits. Subrenal xenografts of ROPV-infected rabbit vulvar and penile sheath tissues were strongly positive for ROPV infection by histologic, in situ hybridization, and Southern analyses. Direct inoculation of adult rabbit penises with infectious ROPV produced small raised lesions of approximately 1 by 1 by 1 mm that were ROPV positive by both in situ hybridization and Southern analyses and were also viral capsid antigen positive by immunohistological staining. Infection of rabbit genital tissues with ROPV may be a useful animal model for the study of genital tissue-targeting papillomaviruses.

* Corresponding author. Mailing address: Department of Pathology, The Jake Gittlen Cancer Research Institute, The Milton S. Hershey Medical Center, Pennsylvania State University, P.O. Box 850, Hershey, PA 17033. Phone: (717) 531-6185. Fax: (717) 531-5634. E-mail: ndc1{at}psu.edu.

J Virol, June 1998, p. 5239-5244, Vol. 72, No. 6
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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