This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Linn, M. L.
Right arrow Articles by Suhrbier, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Linn, M. L.
Right arrow Articles by Suhrbier, A.

 Previous Article  |  Next Article 

J Virol, June 1998, p. 5146-5153, Vol. 72, No. 6
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Alphavirus-Specific Cytotoxic T Lymphocytes Recognize a Cross-Reactive Epitope from the Capsid Protein and Can Eliminate Virus from Persistently Infected Macrophages

May La Linn, L. Mateo, J. Gardner, and A. Suhrbier*

Queensland Institute of Medical Research, Brisbane, Queensland, Australia

Received 1 December 1997/Accepted 24 February 1998

Persistent alphavirus infections in synovial and neural tissues are believed to be associated with chronic arthritis and encephalitis, respectively, and represent likely targets for CD8+ alpha beta cytotoxic T lymphocytes (CTL). Here we show that the capsid protein is a dominant target for alphavirus-specific CTL in BALB/c mice and that capsid-specific CTL from these mice recognize an H-2Kd restricted epitope, QYSGGRFTI. This epitope lies in the highly conserved region of the capsid protein, and QYSGGRFTI-specific CTL were cross reactive across a range of Old World alphaviruses. In vivo the acute primary viraemia of these highly cytopathic viruses was unaffected by QYSGGRFTI-specific CTL. However, in vitro these CTL were able to completely clear virus from macrophages persistently and productively infected with the arthrogenic alphavirus Ross River virus.

* Corresponding author. Mailing address: Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, Qld. 4029, Australia. Phone: 61-7-33620415. Fax: 61-7-33620106. E-mail: andreasS{at}qimr.edu.au.

J Virol, June 1998, p. 5146-5153, Vol. 72, No. 6
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Powers, A. M., Logue, C. H. (2007). Changing patterns of chikungunya virus: re-emergence of a zoonotic arbovirus. J. Gen. Virol. 88: 2363-2377 [Full Text]  
  • Krymskaya, L., Sharma, M. C., Martinez, J., Haq, W., Huang, E. C., Limaye, A. P., Diamond, D. J., Lacey, S. F. (2005). Cross-Reactivity of T Lymphocytes Recognizing a Human Cytotoxic T-Lymphocyte Epitope within BK and JC Virus VP1 Polypeptides. J. Virol. 79: 11170-11178 [Abstract] [Full Text]  
  • Woodberry, T., Gardner, J., Elliott, S. L., Leyrer, S., Purdie, D. M., Chaplin, P., Suhrbier, A. (2003). Prime Boost Vaccination Strategies: CD8 T Cell Numbers, Protection, and Th1 Bias. J. Immunol. 170: 2599-2604 [Abstract] [Full Text]  
  • Harley, D., Sleigh, A., Ritchie, S. (2001). Ross River Virus Transmission, Infection, and Disease: a Cross-Disciplinary Review. Clin. Microbiol. Rev. 14: 909-932 [Abstract] [Full Text]  
  • Woodberry, T., Gardner, J., Mateo, L., Eisen, D., Medveczky, J., Ramshaw, I. A., Thomson, S. A., Ffrench, R. A., Elliott, S. L., Firat, H., Lemonnier, F. A., Suhrbier, A. (1999). Immunogenicity of a Human Immunodeficiency Virus (HIV) Polytope Vaccine Containing Multiple HLA A2 HIV CD8+ Cytotoxic T-Cell Epitopes. J. Virol. 73: 5320-5325 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»