This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Monteiro, J. M.
Right arrow Articles by Trinchieri, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Monteiro, J. M.
Right arrow Articles by Trinchieri, G.

 Previous Article  |  Next Article 

J Virol, June 1998, p. 4825-4831, Vol. 72, No. 6
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Role of Interleukin-12 in Primary Influenza Virus Infection

Juanita M. Monteiro,1,dagger Catherine Harvey,2 and Giorgio Trinchieri1,*

Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104,1 and University of Wisconsin, Madison, Wisconsin 535902

Received 15 September 1997/Accepted 10 March 1998

The effect of endogenous interleukin-12 (IL-12) on the influenza virus immune response in BALB/c mice was evaluated. Following primary influenza virus infection, IL-12 mRNA and protein are detected in the lung, with live virus being required for cytokine induction. Endogenous IL-12 contributes to early NK cell-dependent gamma interferon (IFN-gamma ) production (days 3 and 5) but not late T-cell-dependent IFN-gamma secretion (day 7). IL-12 contributes to the inhibition of early virus replication but is not required for virus clearance. IL-12 also modestly contributes to the activation of cytotoxic T lymphocytes. Thus, in this model of experimental influenza virus infection, endogenous IL-12 contributes primarily to the early development and activation of the innate immune response.

* Corresponding author. Mailing address: The Wistar Institute, 3601 Spruce St., Philadelphia, PA 19104. Phone: (215) 898-3992. Fax: (215) 898-2357. E-mail: trinchieri{at}wista.wistar.upenn.edu.

dagger Present address: Merck Research Laboratories, Merck & Co., Inc., West Point, Pa.

J Virol, June 1998, p. 4825-4831, Vol. 72, No. 6
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Kapil, P., Atkinson, R., Ramakrishna, C., Cua, D. J., Bergmann, C. C., Stohlman, S. A. (2009). Interleukin-12 (IL-12), but Not IL-23, Deficiency Ameliorates Viral Encephalitis without Affecting Viral Control. J. Virol. 83: 5978-5986 [Abstract] [Full Text]  
  • de Boer, T., van Dissel, J. T., Kuijpers, T. W. J., Rimmelzwaan, G. F., Kroon, F. P., Ottenhoff, T. H. M. (2008). Influenza Virus Vaccination Induces Interleukin-12/23 Receptor {beta}1 (IL-12/23R{beta}1)-Independent Production of Gamma Interferon (IFN-{gamma}) and Humoral Immunity in Patients with Genetic Deficiencies in IL-12/23R{beta}1 or IFN-{gamma} Receptor I. CVI 15: 1171-1175 [Abstract] [Full Text]  
  • Ruan, S., McKinley, L., Zheng, M., Rudner, X., D'Souza, A., Kolls, J. K., Shellito, J. E. (2008). Interleukin-12 and Host Defense against Murine Pneumocystis Pneumonia. Infect. Immun. 76: 2130-2137 [Abstract] [Full Text]  
  • Gabriel, G., Nordmann, A., Stein, D. A., Iversen, P. L., Klenk, H.-D. (2008). Morpholino oligomers targeting the PB1 and NP genes enhance the survival of mice infected with highly pathogenic influenza A H7N7 virus. J. Gen. Virol. 89: 939-948 [Abstract] [Full Text]  
  • Reading, P. C., Whitney, P. G., Barr, D. P., Wojtasiak, M., Mintern, J. D., Waithman, J., Brooks, A. G. (2007). IL-18, but not IL-12, Regulates NK Cell Activity following Intranasal Herpes Simplex Virus Type 1 Infection. J. Immunol. 179: 3214-3221 [Abstract] [Full Text]  
  • Neff-LaFord, H., Teske, S., Bushnell, T. P., Lawrence, B. P. (2007). Aryl Hydrocarbon Receptor Activation during Influenza Virus Infection Unveils a Novel Pathway of IFN-{gamma} Production by Phagocytic Cells. J. Immunol. 179: 247-255 [Abstract] [Full Text]  
  • Furze, R. C., Hussell, T., Selkirk, M. E. (2006). Amelioration of Influenza-Induced Pathology in Mice by Coinfection with Trichinella spiralis. Infect. Immun. 74: 1924-1932 [Abstract] [Full Text]  
  • Williams, A. P., Bateman, A. R., Khakoo, S. I. (2005). HANGING IN THE BALANCE: KIR and Their Role in Disease. Mol. Interv. 5: 226-240 [Abstract] [Full Text]  
  • Lipatov, A. S., Andreansky, S., Webby, R. J., Hulse, D. J., Rehg, J. E., Krauss, S., Perez, D. R., Doherty, P. C., Webster, R. G., Sangster, M. Y. (2005). Pathogenesis of Hong Kong H5N1 influenza virus NS gene reassortants in mice: the role of cytokines and B- and T-cell responses. J. Gen. Virol. 86: 1121-1130 [Abstract] [Full Text]  
  • Mathers, A. R., Cuff, C. F. (2004). Role of Interleukin-4 (IL-4) and IL-10 in Serum Immunoglobulin G Antibody Responses following Mucosal or Systemic Reovirus Infection. J. Virol. 78: 3352-3360 [Abstract] [Full Text]  
  • Trifilo, M. J., Montalto-Morrison, C., Stiles, L. N., Hurst, K. R., Hardison, J. L., Manning, J. E., Masters, P. S., Lane, T. E. (2004). CXC Chemokine Ligand 10 Controls Viral Infection in the Central Nervous System: Evidence for a Role in Innate Immune Response through Recruitment and Activation of Natural Killer Cells. J. Virol. 78: 585-594 [Abstract] [Full Text]  
  • Alt, J. A., Obal, F. Jr., Traynor, T. R., Gardi, J., Majde, J. A., Krueger, J. M. (2003). Alterations in EEG activity and sleep after influenza viral infection in GHRH receptor-deficient mice. J. Appl. Physiol. 95: 460-468 [Abstract] [Full Text]  
  • Dong, L., Mori, I., Hossain, Md. J., Liu, B., Kimura, Y. (2003). An immunostimulatory oligodeoxynucleotide containing a cytidine-guanosine motif protects senescence-accelerated mice from lethal influenza virus by augmenting the T helper type 1 response. J. Gen. Virol. 84: 1623-1628 [Abstract] [Full Text]  
  • Bot, A., Rodrigo, E., Wolfe, T., Bot, S., Von Herrath, M. G. (2003). Infection-Triggered Regulatory Mechanisms Override the Role of STAT 4 in Control of the Immune Response to Influenza Virus Antigens. J. Virol. 77: 5794-5800 [Abstract] [Full Text]  
  • Pirhonen, J., Matikainen, S., Julkunen, I. (2002). Regulation of Virus-Induced IL-12 and IL-23 Expression in Human Macrophages. J. Immunol. 169: 5673-5678 [Abstract] [Full Text]  
  • Kumaraguru, U., Rouse, B. T. (2002). The IL-12 response to herpes simplex virus is mainly a paracrine response of reactive inflammatory cells. J. Leukoc. Biol. 72: 564-570 [Abstract] [Full Text]  
  • Palma, J. P., Yauch, R. L., Kang, H.-K., Lee, H.-G., Kim, B. S. (2002). Preferential Induction of IL-10 in APC Correlates with a Switch from Th1 to Th2 Response Following Infection with a Low Pathogenic Variant of Theiler's Virus. J. Immunol. 168: 4221-4230 [Abstract] [Full Text]  
  • Asahi, Y., Yoshikawa, T., Watanabe, I., Iwasaki, T., Hasegawa, H., Sato, Y., Shimada, S.-i., Nanno, M., Matsuoka, Y., Ohwaki, M., Iwakura, Y., Suzuki, Y., Aizawa, C., Sata, T., Kurata, T., Tamura, S.-i. (2002). Protection Against Influenza Virus Infection in Polymeric Ig Receptor Knockout Mice Immunized Intranasally with Adjuvant-Combined Vaccines. J. Immunol. 168: 2930-2938 [Abstract] [Full Text]  
  • Boyton, R. J, Openshaw, P. J (2002). Pulmonary defences to acute respiratory infection. Br Med Bull 61: 1-12 [Abstract] [Full Text]  
  • Muller, U., Kohler, G., Mossmann, H., Schaub, G. A., Alber, G., Di Santo, J. P., Brombacher, F., Holscher, C. (2001). IL-12-Independent IFN-{gamma} Production by T Cells in Experimental Chagas' Disease Is Mediated by IL-18. J. Immunol. 167: 3346-3353 [Abstract] [Full Text]  
  • Tsurita, M., Kurokawa, M., Imakita, M., Fukuda, Y., Watanabe, Y., Shiraki, K. (2001). Early Augmentation of Interleukin (IL)-12 Level in the Airway of Mice Administered Orally with Clarithromycin or Intranasally with IL-12 Results in Alleviation of Influenza Infection. J. Pharmacol. Exp. Ther. 298: 362-368 [Abstract] [Full Text]  
  • Rudolf, M. P., Fausch, S. C., Da Silva, D. M., Kast, W. M. (2001). Human Dendritic Cells Are Activated by Chimeric Human Papillomavirus Type-16 Virus-Like Particles and Induce Epitope-Specific Human T Cell Responses In Vitro. J. Immunol. 166: 5917-5924 [Abstract] [Full Text]  
  • Hori, T., Kiyoshima, J., Shida, K., Yasui, H. (2001). Effect of Intranasal Administration of Lactobacillus casei Shirota on Influenza Virus Infection of Upper Respiratory Tract in Mice. CVI 8: 593-597 [Abstract] [Full Text]  
  • Mogensen, T. H., Paludan, S. R. (2001). Molecular Pathways in Virus-Induced Cytokine Production. Microbiol. Mol. Biol. Rev. 65: 131-150 [Abstract] [Full Text]  
  • Malmgaard, L., Paludan, S. R., Mogensen, S. C., Ellermann-Eriksen, S. (2000). Herpes simplex virus type 2 induces secretion of IL-12 by macrophages through a mechanism involving NF-{kappa}B. J. Gen. Virol. 81: 3011-3020 [Abstract] [Full Text]  
  • Warren, T. K., Mitchell, K. A., Lawrence, B. P. (2000). Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Suppresses the Humoral and Cell-Mediated Immune Responses to Influenza A Virus without Affecting Cytolytic Activity in the Lung. Toxicol Sci 56: 114-123 [Abstract] [Full Text]  
  • Arulanandam, B. P., Mittler, J. N., Lee, W. T., O'Toole, M., Metzger, D. W. (2000). Neonatal Administration of IL-12 Enhances the Protective Efficacy of Antiviral Vaccines. J. Immunol. 164: 3698-3704 [Abstract] [Full Text]  
  • Xing, Z., Zganiacz, A., Wang, J., Divangahi, M., Nawaz, F. (2000). IL-12-Independent Th1-Type Immune Responses to Respiratory Viral Infection: Requirement of IL-18 for IFN-{gamma} Release in the Lung But Not for the Differentiation of Viral-Reactive Th1-Type Lymphocytes. J. Immunol. 164: 2575-2584 [Abstract] [Full Text]  
  • Pien, G. C., Biron, C. A. (2000). Compartmental Differences in NK Cell Responsiveness to IL-12 During Lymphocytic Choriomeningitis Virus Infection. J. Immunol. 164: 994-1001 [Abstract] [Full Text]  
  • Gherardi, M. M., Ramirez, J. C., Rodriguez, D., Rodriguez, J. R., Sano, G.-I., Zavala, F., Esteban, M. (1999). IL-12 Delivery from Recombinant Vaccinia Virus Attenuates the Vector and Enhances the Cellular Immune Response Against HIV-1 Env in a Dose-Dependent Manner. J. Immunol. 162: 6724-6733 [Abstract] [Full Text]  
  • Nguyen, K. B., Biron, C. A. (1999). Synergism for Cytokine-Mediated Disease During Concurrent Endotoxin and Viral Challenges: Roles for NK and T Cell IFN-{gamma} Production. J. Immunol. 162: 5238-5246 [Abstract] [Full Text]  
  • Cousens, L. P., Peterson, R., Hsu, S., Dorner, A., Altman, J. D., Ahmed, R., Biron, C. A. (1999). Two Roads Diverged: Interferon alpha /beta - and Interleukin 12-mediated Pathways in Promoting T Cell Interferon gamma  Responses during Viral Infection. JEM 189: 1315-1328 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»