This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nguyen, H. H.
Right arrow Articles by Mestecky, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nguyen, H. H.
Right arrow Articles by Mestecky, J.

 Previous Article  |  Next Article 

J Virol, May 1998, p. 4534-4536, Vol. 72, No. 5
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Influenza Virus-Infected Epithelial Cells Present Viral Antigens to Antigen-Specific CD8+ Cytotoxic T Lymphocytes

Huan H. Nguyen,1,* Prosper N. Boyaka,1 Zina Moldoveanu,1 Miroslav J. Novak,1 Hiroshi Kiyono,1,2 Jerry R. McGhee,1 and Jiri Mestecky1

Department of Microbiology and The Immunobiology Vaccine Center, University of Alabama at Birmingham, Birmingham, Alabama 35294-2170,1 and Department of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan2

Received 27 August 1997/Accepted 20 January 1998

We have investigated the mechanisms involved in the clearance of viral infection at the epithelium level by analyzing the activity of influenza virus-specific cytotoxic T lymphocytes (CTL) against virus-infected CMT-93 intestinal epithelial cells. Epithelial cells infected with live influenza virus effectively present viral antigens and were lysed by both homotypic and heterotypic influenza virus-specific CD8+ T cells. These results shed new light on the control of viral infection through the elimination of virus-infected epithelial cells by virus-specific CTL and demonstrate that CMT-93 cells furnish an appropriate model for in vitro evaluation of CTL activity against virus-infected epithelial cells.

* Corresponding author. Mailing address: Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294-2170. Phone: (205) 934-1234. Fax: (205) 934-3894. E-mail: nghuan{at}uab.edu.

J Virol, May 1998, p. 4534-4536, Vol. 72, No. 5
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Schwerbrock, N. M. J., Karlsson, E. A., Shi, Q., Sheridan, P. A., Beck, M. A. (2009). Fish Oil-Fed Mice Have Impaired Resistance to Influenza Infection. J. Nutr. 139: 1588-1594 [Abstract] [Full Text]  
  • Proud, D., Chow, C.-W. (2006). Role of Viral Infections in Asthma and Chronic Obstructive Pulmonary Disease. Am. J. Respir. Cell Mol. Bio. 35: 513-518 [Abstract] [Full Text]  
  • Suzuki, A., Hanada, T., Mitsuyama, K., Yoshida, T., Kamizono, S., Hoshino, T., Kubo, M., Yamashita, A., Okabe, M., Takeda, K., Akira, S., Matsumoto, S., Toyonaga, A., Sata, M., Yoshimura, A. (2001). Cis3/Socs3/Ssi3 Plays a Negative Regulatory Role in Stat3 Activation and Intestinal Inflammation. JEM 193: 471-482 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»