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J Virol, May 1998, p. 4508-4514, Vol. 72, No. 5
Virology Unit, Department of Infectious
Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht
University, Utrecht, The Netherlands
Received 5 November 1997/Accepted 10 February 1998
Recent evidence suggests that the type II feline coronavirus (FCoV)
strains 79-1146 and 79-1683 have arisen from a homologous RNA
recombination event between FCoV type I and canine coronavirus (CCV).
In both cases, the template switch apparently took place between the S
and M genes, giving rise to recombinant viruses which encode a CCV-like
S protein and the M, N, 7a, and 7b proteins of FCoV type I (K. Motowaka, T. Hoh- datsu, H. Hashimoto, and H. Koyama,
Microbiol. Immunol. 40:425-433, 1996; H. Vennema, A. Poland, K. Floyd Hawkins, and N. C. Pedersen, Feline Pract. 23:40-44, 1995).
In the present study, we have looked for additional FCoV-CCV recombination sites. Four regions in the pol gene were
selected for comparative sequence analysis of the type II FCoV strains 79-1683 and 79-1146, the type I FCoV strains TN406 and UCD1, the CCV
strain K378, and the TGEV strain Purdue. Our data show that the type II
FCoVs have arisen from double recombination events: additional
crossover sites were mapped in the ORF1ab frameshifting region of
strain 79-1683 and in the 5' half of ORF1b of strain 79-1146.
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
Feline Coronavirus Type II Strains 79-1683 and 79-1146 Originate
from a Double Recombination between Feline Coronavirus Type I and
Canine Coronavirus
*
Corresponding author. Mailing address: Virology Unit,
Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, POB 80.165, 3508 TD Utrecht, The Netherlands. Phone: 31-30-2532460. Fax: 31-30-2536723. E-mail: R.Groot{at}vetmic.dgk.ruu.nl.
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