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J Virol, April 1998, p. 3479-3483, Vol. 72, No. 4
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Induction of Mucosal B-Cell Memory by Intramuscular Inoculation of Mice with Rotavirus

Susan E. Coffin1,2,* and Paul A. Offit1,2,3

Division of Immunologic and Infectious Diseases, The Children's Hospital of Philadelphia,1 The University of Pennsylvania School of Medicine,2 and The Wistar Institute of Anatomy and Biology,3 Philadelphia, Pennsylvania 19104

Received 10 November 1997/Accepted 17 December 1997

We investigated the capacity of intramuscular (i.m.) immunization with heterologous-host rotavirus (simian strain RRV) to induce mucosal virus-specific memory B cells in mice. We found that prior i.m. immunization enhanced the magnitude of mucosal virus-specific immunoglobulin A (IgA) production but did not alter the site and timing of induction of virus-specific IgA responses after challenge.

* Corresponding author. Mailing address: Division of Immunologic and Infectious Diseases, The Children's Hospital of Philadelphia, 34th St. and Civic Center Blvd., Philadelphia, PA 19104. Phone: (215) 590-4492. Fax: (215) 590-2025. E-mail: coffin{at}email.chop.edu.




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