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J Virol, April 1998, p. 3469-3471, Vol. 72, No. 4
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
T-Cell Lymphoma Caused by Herpesvirus Saimiri C488
Independently of ie14/vsag, a Viral Gene with
Superantigen Homology
Andrea
Knappe,1
Mathias
Thurau,1
Henk
Niphuis,2
Christian
Hiller,1
Sabine
Wittmann,1
Eva-Maria
Kuhn,2
Brigitte
Rosenwirth,2
Bernhard
Fleckenstein,1
Jonathan
Heeney,2 and
Helmut
Fickenscher1,*
Institut für Klinische und Molekulare
Virologie, Friedrich-Alexander-Universität
Erlangen-Nürnberg, D-91054 Erlangen,
Germany,1 and
Departments of Virology
and Pathology, Biomedical Primate Research Centre, NL-2280 GH
Rijswijk, The Netherlands2
Received 17 October 1997/Accepted 19 December 1997
The immediate-early gene ie14/vsag of herpesvirus
saimiri has homology with murine superantigens. We compared the
pathogenesis of infection with either ie14/vsag deletion
mutants or wild-type virus C488 in cottontop tamarin monkeys
(Saguinus oedipus). Two weeks after infection, all animals
developed acute T-cell lymphomas independently of the presence of the
viral ie14/vsag gene.
*
Corresponding author. Mailing address: Institut
für Klinische und Molekulare Virologie der
Friedrich-Alexander-Universität Erlangen-Nürnberg,
Schlossgarten 4, D-91054 Erlangen, Germany. Phone: 49-9131-85-3786. Fax: 49-9131-85-6493. E-mail:
helmutfr{at}viro.med.uni-erlangen.de.
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