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J Virol, April 1998, p. 3469-3471, Vol. 72, No. 4
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

T-Cell Lymphoma Caused by Herpesvirus Saimiri C488 Independently of ie14/vsag, a Viral Gene with Superantigen Homology

Andrea Knappe,1 Mathias Thurau,1 Henk Niphuis,2 Christian Hiller,1 Sabine Wittmann,1 Eva-Maria Kuhn,2 Brigitte Rosenwirth,2 Bernhard Fleckenstein,1 Jonathan Heeney,2 and Helmut Fickenscher1,*

Institut für Klinische und Molekulare Virologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, D-91054 Erlangen, Germany,1 and Departments of Virology and Pathology, Biomedical Primate Research Centre, NL-2280 GH Rijswijk, The Netherlands2

Received 17 October 1997/Accepted 19 December 1997

The immediate-early gene ie14/vsag of herpesvirus saimiri has homology with murine superantigens. We compared the pathogenesis of infection with either ie14/vsag deletion mutants or wild-type virus C488 in cottontop tamarin monkeys (Saguinus oedipus). Two weeks after infection, all animals developed acute T-cell lymphomas independently of the presence of the viral ie14/vsag gene.

* Corresponding author. Mailing address: Institut für Klinische und Molekulare Virologie der Friedrich-Alexander-Universität Erlangen-Nürnberg, Schlossgarten 4, D-91054 Erlangen, Germany. Phone: 49-9131-85-3786. Fax: 49-9131-85-6493. E-mail: helmutfr{at}viro.med.uni-erlangen.de.




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