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J Virol, April 1998, p. 3370-3376, Vol. 72, No. 4
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

A Cytopathogenic, Apoptosis-Inducing Variant of Hepatitis A Virusdagger

Kerstin Brack, Werner Frings, Andreas Dotzauer,* and Angelika Vallbracht

Department of Virology, University of Bremen, D-28211 Bremen, Germany

Received 28 July 1997/Accepted 22 December 1997

A cytopathogenic variant of hepatitis A virus (HAVcyt/HB1.1) was isolated from persistently infected BS-C-1 cells by serial passages in FRhK-4 cells. This virus shows a rapid replication pattern and high final titers are obtained, which are main characteristics of cytopathogenic HAVs. Sequencing of the nontranslated regions and the coding regions for 2ABC and 3AB revealed that mutations are distributed all over these regions and that certain mutated sites correspond to those in other cytopathogenic HAV variants. Investigating the mechanisms causing the cytopathic effect in FRhK-4 cells infected with this variant, we found that an apoptotic reaction takes place.

* Corresponding author. Mailing address: Department of Virology, University of Bremen, Argonnenstr. 3, D-28211 Bremen, Germany. Phone: 421-218-4354. Fax: 421-218-4266. E-mail: dotzauer{at}uni-bremen.de.

dagger This work is dedicated to H.-J. Gerth on the occasion of his 70th birthday.




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