This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cavanaugh, V. J.
Right arrow Articles by Chisari, F. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cavanaugh, V. J.
Right arrow Articles by Chisari, F. V.

 Previous Article  |  Next Article 

J Virol, April 1998, p. 2630-2637, Vol. 72, No. 4
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Inhibition of Hepatitis B Virus Replication during Adenovirus and Cytomegalovirus Infections in Transgenic Micedagger

Victoria J. Cavanaugh, Luca G. Guidotti, and Francis V. Chisari*

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037

Received 30 September 1997/Accepted 16 December 1997

We have previously demonstrated that hepatitis B virus (HBV) replication and gene expression are abolished in the livers of HBV transgenic mice by cytotoxic T lymphocytes (CTLs) and during lymphocytic choriomeningitis virus (LCMV) infection, stimuli that trigger the production of alpha/beta interferon, gamma interferon, and tumor necrosis factor alpha in the liver. We now report that hepatic HBV replication and gene expression are inhibited by the local induction of these cytokines during adenovirus- and murine cytomegalovirus (MCMV)-induced hepatitis. Further, we show that MCMV also blocks HBV replication and gene expression in the proximal convoluted tubules of the kidney by causing interstitial nephritis and inducing the same cytokines in the renal parenchyma. These results suggest that inflammatory cytokines probably contribute to viral clearance during acute viral hepatitis in humans, and they imply that induction of these cytokines in the liver and other infected tissues of chronically infected patients might have therapeutic value.

* Corresponding author. Mailing address: Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037. Phone: (619) 784-8228. Fax: (619) 784-2160. E-mail: fchisari{at}scripps.edu.

dagger Manuscript no. 10943-MEM from the Scripps Research Institute.




This article has been cited by other articles:

  • Kanda, T., Steele, R., Ray, R., Ray, R. B. (2009). Inhibition of Intrahepatic Gamma Interferon Production by Hepatitis C Virus Nonstructural Protein 5A in Transgenic Mice. J. Virol. 83: 8463-8469 [Abstract] [Full Text]  
  • Turelli, P., Liagre-Quazzola, A., Mangeat, B., Verp, S., Jost, S., Trono, D. (2008). APOBEC3-Independent Interferon-Induced Viral Clearance in Hepatitis B Virus Transgenic Mice. J. Virol. 82: 6585-6590 [Abstract] [Full Text]  
  • Oropeza, C. E., Li, L., McLachlan, A. (2008). Differential Inhibition of Nuclear Hormone Receptor-Dependent Hepatitis B Virus Replication by the Small Heterodimer Partner. J. Virol. 82: 3814-3821 [Abstract] [Full Text]  
  • Iannacone, M., Sitia, G., Isogawa, M., Whitmire, J. K., Marchese, P., Chisari, F. V., Ruggeri, Z. M., Guidotti, L. G. (2008). Platelets prevent IFN-{alpha}/ -induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus. Proc. Natl. Acad. Sci. USA 105: 629-634 [Abstract] [Full Text]  
  • Jost, S., Turelli, P., Mangeat, B., Protzer, U., Trono, D. (2007). Induction of Antiviral Cytidine Deaminases Does Not Explain the Inhibition of Hepatitis B Virus Replication by Interferons. J. Virol. 81: 10588-10596 [Abstract] [Full Text]  
  • Narayan, R., Buronfosse, T., Schultz, U., Chevallier-Gueyron, P., Guerret, S., Chevallier, M., Saade, F., Ndeboko, B., Trepo, C., Zoulim, F., Cova, L. (2006). Rise in gamma interferon expression during resolution of duck hepatitis B virus infection.. J. Gen. Virol. 87: 3225-3232 [Abstract] [Full Text]  
  • Zirger, J. M., Barcia, C., Liu, C., Puntel, M., Mitchell, N., Campbell, I., Castro, M., Lowenstein, P. R. (2006). Rapid Upregulation of Interferon-Regulated and Chemokine mRNAs upon Injection of 108 International Units, but Not Lower Doses, of Adenoviral Vectors into the Brain.. J. Virol. 80: 5655-5659 [Abstract] [Full Text]  
  • Wieland, S. F., Chisari, F. V. (2005). Stealth and Cunning: Hepatitis B and Hepatitis C Viruses. J. Virol. 79: 9369-9380 [Full Text]  
  • Isogawa, M., Robek, M. D., Furuichi, Y., Chisari, F. V. (2005). Toll-Like Receptor Signaling Inhibits Hepatitis B Virus Replication In Vivo. J. Virol. 79: 7269-7272 [Abstract] [Full Text]  
  • Fiedler, M., Rodicker, F., Salucci, V., Lu, M., Aurisicchio, L., Dahmen, U., Jun, L., Dirsch, O., Putzer, B. M., Palombo, F., Roggendorf, M. (2004). Helper-Dependent Adenoviral Vector-Mediated Delivery of Woodchuck-Specific Genes for Alpha Interferon (IFN-{alpha}) and IFN-{gamma}: IFN-{alpha} but Not IFN-{gamma} Reduces Woodchuck Hepatitis Virus Replication in Chronic Infection In Vivo. J. Virol. 78: 10111-10121 [Abstract] [Full Text]  
  • Ganem, D., Prince, A. M. (2004). Hepatitis B Virus Infection -- Natural History and Clinical Consequences. NEJM 350: 1118-1129 [Full Text]  
  • Robek, M. D., Boyd, B. S., Wieland, S. F., Chisari, F. V. (2004). Signal transduction pathways that inhibit hepatitis B virus replication. Proc. Natl. Acad. Sci. USA 101: 1743-1747 [Abstract] [Full Text]  
  • Summers, J., Jilbert, A. R., Yang, W., Aldrich, C. E., Saputelli, J., Litwin, S., Toll, E., Mason, W. S. (2003). Inaugural Article: Hepatocyte turnover during resolution of a transient hepadnaviral infection. Proc. Natl. Acad. Sci. USA 100: 11652-11659 [Abstract] [Full Text]  
  • Weber, O., Siegling, A., Friebe, A., Limmer, A., Schlapp, T., Knolle, P., Mercer, A., Schaller, H., Volk, H.-D. (2003). Inactivated parapoxvirus ovis (Orf virus) has antiviral activity against hepatitis B virus and herpes simplex virus. J. Gen. Virol. 84: 1843-1852 [Abstract] [Full Text]  
  • Biermer, M., Puro, R., Schneider, R. J. (2003). Tumor Necrosis Factor Alpha Inhibition of Hepatitis B Virus Replication Involves Disruption of Capsid Integrity through Activation of NF-{kappa}B. J. Virol. 77: 4033-4042 [Abstract] [Full Text]  
  • Uprichard, S. L., Wieland, S. F., Althage, A., Chisari, F. V. (2003). Transcriptional and posttranscriptional control of hepatitis B virus gene expression. Proc. Natl. Acad. Sci. USA 100: 1310-1315 [Abstract] [Full Text]  
  • Wieland, S. F., Vega, R. G., Muller, R., Evans, C. F., Hilbush, B., Guidotti, L. G., Sutcliffe, J. G., Schultz, P. G., Chisari, F. V. (2002). Searching for Interferon-Induced Genes That Inhibit Hepatitis B Virus Replication in Transgenic Mouse Hepatocytes. J. Virol. 77: 1227-1236 [Abstract] [Full Text]  
  • Robek, M. D., Wieland, S. F., Chisari, F. V. (2002). Inhibition of Hepatitis B Virus Replication by Interferon Requires Proteasome Activity. J. Virol. 76: 3570-3574 [Abstract] [Full Text]  
  • Kimura, K., Kakimi, K., Wieland, S., Guidotti, L. G., Chisari, F. V. (2002). Activated Intrahepatic Antigen-Presenting Cells Inhibit Hepatitis B Virus Replication in the Liver of Transgenic Mice. J. Immunol. 169: 5188-5195 [Abstract] [Full Text]  
  • Kimura, K., Kakimi, K., Wieland, S., Guidotti, L. G., Chisari, F. V. (2002). Interleukin-18 Inhibits Hepatitis B Virus Replication in the Livers of Transgenic Mice. J. Virol. 76: 10702-10707 [Abstract] [Full Text]  
  • Pasquetto, V., Wieland, S. F., Uprichard, S. L., Tripodi, M., Chisari, F. V. (2002). Cytokine-Sensitive Replication of Hepatitis B Virus in Immortalized Mouse Hepatocyte Cultures. J. Virol. 76: 5646-5653 [Abstract] [Full Text]  
  • Guidotti, L. G., Morris, A., Mendez, H., Koch, R., Silverman, R. H., Williams, B. R. G., Chisari, F. V. (2002). Interferon-Regulated Pathways That Control Hepatitis B Virus Replication in Transgenic Mice. J. Virol. 76: 2617-2621 [Abstract] [Full Text]  
  • Mosier, D. E., Chisari, F. V., Macalalad, A. R., Snydman, D. R., Takamatsu, J., Toyoda, H., Fukuda, Y., Stapleton, J. T., Diekema, D. J., Xiang, J., Tillmann, H. L., Schmidt, R. E., Manns, M. P. (2002). GB Virus C and Mortality from HIV Infection. NEJM 346: 377-379 [Full Text]  
  • Samuel, C. E. (2001). Antiviral Actions of Interferons. Clin. Microbiol. Rev. 14: 778-809 [Abstract] [Full Text]  
  • Topham, D. J., Cardin, R. C., Christensen, J. P., Brooks, J. W., Belz, G. T., Doherty, P. C. (2001). Perforin and Fas in murine gammaherpesvirus-specific CD8+ T cell control and morbidity. J. Gen. Virol. 82: 1971-1981 [Abstract] [Full Text]  
  • Heise, T., Guidotti, L. G., Chisari, F. V. (2001). Characterization of Nuclear RNases That Cleave Hepatitis B Virus RNA near the La Protein Binding Site. J. Virol. 75: 6874-6883 [Abstract] [Full Text]  
  • Zhou, T., Guo, J.-T., Nunes, F. A., Molnar-Kimber, K. L., Wilson, J. M., Aldrich, C. E., Saputelli, J., Litwin, S., Condreay, L. D., Seeger, C., Mason, W. S. (2000). Combination Therapy with Lamivudine and Adenovirus Causes Transient Suppression of Chronic Woodchuck Hepatitis Virus Infections. J. Virol. 74: 11754-11763 [Abstract] [Full Text]  
  • Pasquetto, V., Wieland, S., Chisari, F. V. (2000). Intracellular Hepatitis B Virus Nucleocapsids Survive Cytotoxic T-Lymphocyte-Induced Apoptosis. J. Virol. 74: 9792-9796 [Abstract] [Full Text]  
  • Kakimi, K., Guidotti, L. G., Koezuka, Y., Chisari, F. V. (2000). Natural Killer T Cell Activation Inhibits Hepatitis B Virus Replication in Vivo. JEM 192: 921-930 [Abstract] [Full Text]  
  • Pasquetto, V., Guidotti, L. G., Kakimi, K., Tsuji, M., Chisari, F. V. (2000). Host-Virus Interactions during Malaria Infection in Hepatitis B Virus Transgenic Mice. JEM 192: 529-536 [Abstract] [Full Text]  
  • McClary, H., Koch, R., Chisari, F. V., Guidotti, L. G. (2000). Inhibition of Hepatitis B Virus Replication during Schistosoma mansoni Infection in Transgenic Mice. JEM 192: 289-294 [Abstract] [Full Text]  
  • Pinto, L. A., Blazevic, V., Patterson, B. K., Mac Trubey, C., Dolan, M. J., Shearer, G. M. (2000). Inhibition of Human Immunodeficiency Virus Type 1 Replication prior to Reverse Transcription by Influenza Virus Stimulation. J. Virol. 74: 4505-4511 [Abstract] [Full Text]  
  • Aurisicchio, L., Delmastro, P., Salucci, V., Paz, O. G., Rovere, P., Ciliberto, G., La Monica, N., Palombo, F. (2000). Liver-Specific Alpha 2 Interferon Gene Expression Results in Protection from Induced Hepatitis. J. Virol. 74: 4816-4823 [Abstract] [Full Text]  
  • Wieland, S. F., Guidotti, L. G., Chisari, F. V. (2000). Intrahepatic Induction of Alpha/Beta Interferon Eliminates Viral RNA-Containing Capsids in Hepatitis B Virus Transgenic Mice. J. Virol. 74: 4165-4173 [Abstract] [Full Text]  
  • Schirmbeck, R., Wild, J., Stober, D., Blum, H. E., Chisari, F. V., Geissler, M., Reimann, J. (2000). Ongoing Murine T1 or T2 Immune Responses to the Hepatitis B Surface Antigen Are Excluded from the Liver that Expresses Transgene-Encoded Hepatitis B Surface Antigen. J. Immunol. 164: 4235-4243 [Abstract] [Full Text]  
  • Chisari, F. V. (2000). Viruses, Immunity, and Cancer: Lessons from Hepatitis B. Am. J. Pathol. 156: 1117-1132 [Full Text]  
  • Seeger, C., Mason, W. S. (2000). Hepatitis B Virus Biology. Microbiol. Mol. Biol. Rev. 64: 51-68 [Abstract] [Full Text]  
  • McClary, H., Koch, R., Chisari, F. V., Guidotti, L. G. (2000). Relative Sensitivity of Hepatitis B Virus and Other Hepatotropic Viruses to the Antiviral Effects of Cytokines. J. Virol. 74: 2255-2264 [Abstract] [Full Text]  
  • Schultz, U., Summers, J., Staeheli, P., Chisari, F. V. (1999). Elimination of Duck Hepatitis B Virus RNA-Containing Capsids in Duck Interferon-Alpha-Treated Hepatocytes. J. Virol. 73: 5459-5465 [Abstract] [Full Text]  
  • Heise, T., Guidotti, L. G., Chisari, F. V. (1999). La Autoantigen Specifically Recognizes a Predicted Stem-Loop in Hepatitis B Virus RNA. J. Virol. 73: 5767-5776 [Abstract] [Full Text]  
  • Guidotti, L. G., Borrow, P., Brown, A., McClary, H., Koch, R., Chisari, F. V. (1999). Noncytopathic Clearance of Lymphocytic Choriomeningitis Virus from the Hepatocyte. JEM 189: 1555-1564 [Abstract] [Full Text]  
  • Guidotti, L. G., Rochford, R., Chung, J., Shapiro, M., Purcell, R., Chisari, F. V. (1999). Viral Clearance Without Destruction of Infected Cells During Acute HBV Infection. Science 284: 825-829 [Abstract] [Full Text]  
  • Schultz, U., Chisari, F. V. (1999). Recombinant Duck Interferon Gamma Inhibits Duck Hepatitis B Virus Replication in Primary Hepatocytes. J. Virol. 73: 3162-3168 [Abstract] [Full Text]  
  • Heise, T., Guidotti, L. G., Cavanaugh, V. J., Chisari, F. V. (1999). Hepatitis B Virus RNA-Binding Proteins Associated with Cytokine-Induced Clearance of Viral RNA from the Liver of Transgenic Mice. J. Virol. 73: 474-481 [Abstract] [Full Text]  
  • Rothmann, K., Schnolzer, M., Radziwill, G., Hildt, E., Moelling, K., Schaller, H. (1998). Host Cell-Virus Cross Talk: Phosphorylation of a Hepatitis B Virus Envelope Protein Mediates Intracellular Signaling. J. Virol. 72: 10138-10147 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»