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J Virol, March 1998, p. 2548-2553, Vol. 72, No. 3
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

The Glycoprotein D (US6) Homolog Is Not Essential for Oncogenicity or Horizontal Transmission of Marek's Disease Virusdagger

Amy S. Anderson, Mark S. Parcells,Dagger and Robin W. Morgan*

Delaware Agricultural Experiment Station, Department of Animal and Food Sciences, College of Agricultural Sciences, University of Delaware, Newark, Delaware 19717-1303

Received 9 September 1997/Accepted 4 December 1997

RB1BUS6lacgpt, a Marek's disease virus (MDV) mutant having a disrupted glycoprotein D (gD) homolog gene, established infection and induced tumors in chickens exposed to it by inoculation or by contact. Lymphoblastoid cell lines derived from RB1BUS6lacgpt-induced tumors harbored only the mutant virus. These results provide strong evidence that an intact gD homolog gene is not essential for oncogenicity or horizontal transmission of MDV.

* Corresponding author. Mailing address: Department of Animal and Food Sciences, 040 Townsend Hall, University of Delaware, Newark, DE 19717-1303. Phone: (302) 831-1341. Fax: (302) 831-8177. E-mail: robin.morgan{at}mvs.udel.edu.

dagger Paper no. 1627 in the Journal Series of the Delaware Agricultural Experiment Station.

Dagger Present address: Center of Excellence for Poultry Science, University of Arkansas, Fayetteville, AR 72701.




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