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J Virol, March 1998, p. 2541-2543, Vol. 72, No. 3
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Heterosexual Transmission of a Murine AIDS Virus

Yoshiaki Okada, Eri Abe, Katsutoshi Komuro, and Toshiaki Mizuochi*

Department of Bacterial and Blood Products and Department of Safety Research on Biologics, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo 162, Japan

Received 2 June 1997/Accepted 3 December 1997

Heterosexual transmission of a murine leukemia virus mixture named LP-BM5 MuLV, which is known as the murine AIDS virus, was investigated. Our results indicated that the heterosexual transmission of LP-BM5 MuLV occurs in both directions with high frequency and that the frequencies of virus transmission in the cervix and penis are higher than those in other genital organs. The results suggested that infection by LP-BM5 MuLV via heterosexual transmission may initially take place at particular retrovirus-sensitive sites (cells) in the genital organs.

* Corresponding author. Mailing address: Department of Bacterial and Blood Products, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku-ku, Tokyo 162, Japan. Phone: 81-3-5285-1111. Fax: 81-3-5285-1150. E-mail: miz{at}nih.go.jp






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