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J Virol, March 1998, p. 2483-2490, Vol. 72, No. 3
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Application of a Fas Ligand Encoding a Recombinant Adenovirus Vector for Prolongation of Transgene Expression

Huang-Ge Zhang,1,2 Guadalupe Bilbao,1 Tong Zhou,2 Juan Luis Contreras,1,3 Jesús Gómez-Navarro,1 Meizhen Feng,1 Izumu Saito,4 John D. Mountz,2 and David T. Curiel1,*

Gene Therapy Program,1 Department of Rheumatology,2 and Department of Surgery,3 University of Alabama at Birmingham, Birmingham, Alabama 35294, and Laboratory of Molecular Genetics, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan4

Received 17 July 1997/Accepted 14 November 1997

An adenovirus vector encoding murine Fas ligand (mFasL) under an inducible control was derived. In vivo ectopic expression of mFasL in murine livers induced an inflammatory cellular infiltration. Furthermore, ectopic expression of mFasL by myocytes did not allow prolonged vector-mediated transgene expression. Thus, ectopic expression of functional mFasL in vector-transduced cells does not appear to confer, by itself, an immunoprivileged site sufficient to mitigate adenovirus vector immunogenicity.

* Corresponding author. Mailing address: The University of Alabama at Birmingham, Gene Therapy Program, 1824 Sixth Ave. South, WTI 620, Birmingham, AL 35294. Phone: (205) 934-8627. Fax: (205) 975-7476. E-mail: david.curiel{at}ccc.uab.edu.




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