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J Virol, February 1998, p. 1657-1661, Vol. 72, No. 2
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Visna Virus dUTPase Is Dispensable for Neuropathogenicity

Gudmundur Pétursson,1,2,* Priscilla Turelli,2 Sigrídur Matthíasdóttir,1 Gudmundur Georgsson,1 Ólafur S. Andrésson,1 Sigurbjörg Torsteinsdóttir,1 Robert Vigne,2 Valgerdur Andrésdóttir,1 Eggert Gunnarsson,1 Gudrún Agnarsdóttir,1 and Gilles Quérat2

Institute for Experimental Pathology, University of Iceland, Keldur, 112 Reykjavik, Iceland,1 and INSERM U372, Campus de Luminy, 13276 Marseille, France2

Received 11 June 1997/Accepted 22 October 1997

The major part of the dUTPase-encoding region of the visna virus genome was deleted. Intracerebral injection of the mutant virus resulted in a somewhat reduced viral load compared to that resulting from injection of the wild type, especially in the lungs, but the neuropathogenic effects were comparable. The dUTPase gene is dispensable for induction of lesions in the brain.

* Corresponding author. Mailing address: Institute for Experimental Pathology, University of Iceland, Keldur v/Vesturlandsveg, IS-112 Reykjavik, Iceland. Phone: 354-5674700. Fax: 354-5673979. E-mail: gpet{at}rhi.hi.is.




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