This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kajon, A. E.
Right arrow Articles by Spindler, K. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kajon, A. E.
Right arrow Articles by Spindler, K. R.

 Previous Article  |  Next Article 

J Virol, February 1998, p. 1219-1223, Vol. 72, No. 2
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Distribution of Mouse Adenovirus Type 1 in Intraperitoneally and Intranasally Infected Adult Outbred Mice

Adriana E. Kajon,1 Corrie C. Brown,2 and Katherine R. Spindler1,*

Department of Genetics, Franklin College of Arts and Sciences,1 and Department of Veterinary Pathology, College of Veterinary Medicine,2 University of Georgia, Athens, Georgia

Received 2 September 1997/Accepted 14 October 1997

In situ nucleic acid hybridization and immunohistochemistry were used to determine the histological localization of mouse adenovirus type 1 (MAV-1) during acute infection of adult mice infected either intraperitoneally or intranasally with 1,000 PFU of wild-type virus. Organ samples were collected from days 1 to 17 postinfection for the intraperitoneally infected mice and from days 1 to 13 for the intranasally infected mice. Endothelial cells of the brain and spinal cord showed extensive evidence of MAV-1 infection. Endothelial cells in lungs, kidneys, and other organs were also positive for MAV-1, indicating a widespread involvement of the systemic circulation. The presence of viral nucleic acid and/or antigen was also demonstrated in lymphoid tissue. The spleens, Peyer's patches, and peripheral lymph nodes showed positive staining at various times postinfection in mice infected by either route. Virus-infected cells in the spleen exhibited a stellate shape and were localized to the red pulp and germinal centers, suggesting that they are cells of the mononuclear phagocytic system.

* Corresponding author. Mailing address: Department of Genetics, University of Georgia, Life Sciences Bldg., Athens, GA 30602-7223. Phone: (706) 542-8395. Fax: (706) 542-3910. E-mail: spindler{at}uga.cc.uga.edu.




This article has been cited by other articles:

  • Klempa, B., Kruger, D. H., Auste, B., Stanko, M., Krawczyk, A., Nickel, K. F., Uberla, K., Stang, A. (2009). A Novel Cardiotropic Murine Adenovirus Representing a Distinct Species of Mastadenoviruses. J. Virol. 83: 5749-5759 [Abstract] [Full Text]  
  • Robinson, M., Li, B., Ge, Y., Ko, D., Yendluri, S., Harding, T., VanRoey, M., Spindler, K. R., Jooss, K. (2009). Novel Immunocompetent Murine Tumor Model for Evaluation of Conditionally Replication-Competent (Oncolytic) Murine Adenoviral Vectors. J. Virol. 83: 3450-3462 [Abstract] [Full Text]  
  • Raman, S., Hsu, T.-H., Ashley, S. L., Spindler, K. R. (2009). Usage of Integrin and Heparan Sulfate as Receptors for Mouse Adenovirus Type 1. J. Virol. 83: 2831-2838 [Abstract] [Full Text]  
  • Lenaerts, L., Verbeken, E., De Clercq, E., Naesens, L. (2005). Mouse Adenovirus Type 1 Infection in SCID Mice: an Experimental Model for Antiviral Therapy of Systemic Adenovirus Infections. Antimicrob. Agents Chemother. 49: 4689-4699 [Abstract] [Full Text]  
  • Welton, A. R., Chesler, E. J., Sturkie, C., Jackson, A. U., Hirsch, G. N., Spindler, K. R. (2005). Identification of Quantitative Trait Loci for Susceptibility to Mouse Adenovirus Type 1. J. Virol. 79: 11517-11522 [Abstract] [Full Text]  
  • Fang, L., Spindler, K. R. (2005). E1A-CR3 Interaction-Dependent and -Independent Functions of mSur2 in Viral Replication of Early Region 1A Mutants of Mouse Adenovirus Type 1. J. Virol. 79: 3267-3276 [Abstract] [Full Text]  
  • Fang, L., Stevens, J. L., Berk, A. J., Spindler, K. R. (2004). Requirement of Sur2 for Efficient Replication of Mouse Adenovirus Type 1. J. Virol. 78: 12888-12900 [Abstract] [Full Text]  
  • Moore, M. L., McKissic, E. L., Brown, C. C., Wilkinson, J. E., Spindler, K. R. (2004). Fatal Disseminated Mouse Adenovirus Type 1 Infection in Mice Lacking B Cells or Bruton's Tyrosine Kinase. J. Virol. 78: 5584-5590 [Abstract] [Full Text]  
  • Moore, M. L., Brown, C. C., Spindler, K. R. (2003). T Cells Cause Acute Immunopathology and Are Required for Long-Term Survival in Mouse Adenovirus Type 1-Induced Encephalomyelitis. J. Virol. 77: 10060-10070 [Abstract] [Full Text]  
  • Spindler, K. R., Fang, L., Moore, M. L., Hirsch, G. N., Brown, C. C., Kajon, A. (2001). SJL/J Mice Are Highly Susceptible to Infection by Mouse Adenovirus Type 1. J. Virol. 75: 12039-12046 [Abstract] [Full Text]  
  • Cauthen, A. N., Brown, C. C., Spindler, K. R. (1999). In Vitro and In Vivo Characterization of a Mouse Adenovirus Type 1 Early Region 3 Null Mutant. J. Virol. 73: 8640-8646 [Abstract] [Full Text]  
  • Ying, B., Smith, K., Spindler, K. R. (1998). Mouse Adenovirus Type 1 Early Region 1A Is Dispensable for Growth in Cultured Fibroblasts. J. Virol. 72: 6325-6331 [Abstract] [Full Text]  
  • Smith, K., Brown, C. C., Spindler, K. R. (1998). The Role of Mouse Adenovirus Type 1 Early Region 1A in Acute and Persistent Infections in Mice. J. Virol. 72: 5699-5706 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»