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Journal of Virology, December 1998, p. 9421-9427, Vol. 72, No. 12
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Modulation of Immune System Function by Measles Virus Infection: Role of Soluble Factor and Direct Infection

Robert S. Fujinami,1,* Xinmin Sun,1 Joseph M. Howell,1 James C. Jenkin,2 and James B. Burns1,3

Department of Neurology1 and Department of Hematology,2 University of Utah School of Medicine, Salt Lake City, Utah 84132, and Veterans Affairs Medical Center, Salt Lake City, Utah 841483

Received 13 April 1998/Accepted 27 August 1998

Measles virus infection can result in a variety of immunologic defects. We have begun studies to determine the basis for the lack of immune responsiveness to antigen and mitogen following infection. Here we present data showing that Epstein-Barr virus-transformed B-cell lines infected with measles virus produce a soluble factor that can inhibit antigen-specific T-cell proliferation and inhibit the proliferation of uninfected B cells. The soluble factor was neither interleukin-10, transforming growth factor beta , nor alpha/beta interferon. B cells infected with measles virus or treated with the soluble factor were unable to present antigen to T cells in a manner that supported antigen-specific proliferation. This could represent one mechanism of how measles virus limits T-cell expansion. However, we found that once CD4+ or CD8+ T cells were activated, their cytolytic activity was intact whether infected with measles virus or treated with soluble factor. Thus, while slow to be generated these cytoxic cells could participate in viral clearance.

* Corresponding author. Mailing address: Department of Neurology, University of Utah, 50 North Medical Dr., Salt Lake City, UT 84132. Phone: (801) 585-3305. Fax: (801) 585-3311. E-mail: Robert.Fujinami{at}hsc.utah.edu.

Journal of Virology, December 1998, p. 9421-9427, Vol. 72, No. 12
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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