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Journal of Virology, December 1998, p. 10305-10309, Vol. 72, No. 12
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

A Novel Simian Immunodeficiency Virus (SIVdrl) pol Sequence from the Drill Monkey, Mandrillus leucophaeus

J. P. Clewley,1,* J. C. M. Lewis,2 D. W. G. Brown,1 and E. L. Gadsby3

Virus Reference Division, Central Public Health Laboratory, London,1 and International Zoo Veterinary Group, Keighley,2 United Kingdom, and Drill Rehabilitation and Breeding Center, Calabar, Nigeria3

Received 24 April 1998/Accepted 10 September 1998

The drill monkey has been shown by serology and PCR to harbor a unique simian immunodeficiency virus (SIVdrl). A pol sequence, amplified from uncultured peripheral blood cells, is most closely related to the equivalent SIV sequences from the red-capped mangabey (SIVrcm), the sabaeus African green monkey (SIVagmSAB), and the chimpanzee (SIVcpz) and to the human immunodeficiency virus type 1 (HIV-1) sequence of humans. It is as yet unclear whether SIVdrl has a mosaic genome like SIVrcm and SIVagmSAB, is a member of the SIVcpz/HIV-1 lineage, or represents a novel primate lentivirus lineage.


* Corresponding author. Mailing address: Virus Reference Division, Central Public Health Laboratory, 61 Colindale Ave., London NW9 5HT, United Kingdom. Phone: 44 181 200 4400, ext. 3245. Fax: 44 181 200 1569. E-mail: jclewley{at}hgmp.mrc.ac.uk.


Journal of Virology, December 1998, p. 10305-10309, Vol. 72, No. 12
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.



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