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Journal of Virology, December 1998, p. 10270-10274, Vol. 72, No. 12
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Antibody Neutralization-Resistant Primary Isolates of Human Immunodeficiency Virus Type 1

Paul W. H. I. Parren,1,* Meng Wang,1 Alexandra Trkola,2 James M. Binley,2 Martin Purtscher,3 Hermann Katinger,3 John P. Moore,2 and Dennis R. Burton1,*

Departments of Immunology and Molecular Biology, The Scripps Research Institute, La Jolla, California 920371; Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 100162; and Institute of Applied Microbiology, Vienna, Austria3

Received 3 February 1998/Accepted 12 August 1998

Although typical primary isolates of human immunodeficiency virus type 1 (HIV-1) are relatively neutralization resistant, three human monoclonal antibodies and a small number of HIV-1+ human sera that neutralize the majority of isolates have been described. The monoclonal antibodies (2G12, 2F5, and b12) represent specificities that a putative vaccine should aim to elicit, since in vitro neutralization has been correlated with protection against primary viruses in animal models. Furthermore, a neutralization escape mutant to one of the antibodies (b12) selected in vitro remains sensitive to neutralization by the other two (2G12 and 2F5) (H. Mo, L. Stamatatos, J. E. Ip, C. F. Barbas, P. W. H. I. Parren, D. R. Burton, J. P. Moore, and D. D. Ho, J. Virol. 71:6869-6874, 1997), supporting the notion that eliciting a combination of such specificities would be particularly advantageous. Here, however, we describe a small subset of viruses, mostly pediatric, which show a high level of neutralization resistance to all three human monoclonal antibodies and to two broadly neutralizing sera. Such viruses threaten antibody-based antiviral strategies, and the basis for their resistance should be explored.

* Corresponding author. Mailing address for Paul W. H. I. Parren: The Scripps Research Institute, Department of Immunology, IMM2, 10550 N. Torrey Pines Rd., La Jolla, CA 92037. Phone: (619) 784-9298. Fax: (619) 784-8360. E-mail: parren{at}scripps.edu. Mailing address for Dennis R. Burton: The Scripps Research Institute, Department of Immunology, IMM2, 10550 N. Torrey Pines Rd., La Jolla, CA 92037. Phone: (619) 784-9298. Fax: (619) 784-8360. E-mail: burton{at}scripps.edu.

Journal of Virology, December 1998, p. 10270-10274, Vol. 72, No. 12
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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